Results 11 to 20 of about 11,382 (203)

NF-κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor-Resistant Cutaneous T-Cell Lymphoma. [PDF]

Cancer Sci
We identified a novel mechanism of resistance to histone deacetylase inhibitors (HDACi) in cutaneous T‐cell lymphoma (CTCL), mediated by NF‐κB activation. This finding highlights NF‐κB as a potential therapeutic target for overcoming HDACi resistance in CTCL.
Takahashi Y, Kitadate A, Iwama S, Kuroki W, Abe K, Yamada M, Ikeda S, Tagawa H, Wakui H, Hikida M, Takahashi N.   +10 more
europepmc   +2 more sources

Allogeneic haematopoietic cell transplant in cutaneous T-cell lymphomas: Recommendations from the EBMT PH&G Committee. [PDF]

J Eur Acad Dermatol Venereol
This EBMT Practice Harmonisation and Guidelines Committee consensus provides practical recommendations for the selection, timing and conduct of allogeneic transplantation in advanced‐stage mycosis fungoides and Sézary syndrome, aiming to optimize outcomes through early multidisciplinary collaboration and evidence‐based decision‐making.
Damaj G, de Masson A, Dreger P, Bazarbachi A, Berning P, Duarte RF, Fox CP, Guenova E, Hermine O, Kyriakou C, Tanase A, Tournilhac O, Jurczak W, Karsten IE, Quoc SN, Serroukh Y, Stella F, Wulf G, Sureda A, Papadavid E, Ortiz-Romero PL, Ruggeri A, Sánchez-Ortega I, Scarisbrick JJ, Yakoub-Agha I, Onida F, Schmitz N.   +26 more
europepmc   +2 more sources

Mast Cells Are Abundant in Primary Cutaneous T-Cell Lymphomas: Results from a Computer-Aided Quantitative Immunohistological Study. [PDF]

PLoS ONE, 2016
Mast cells (MC) are bone marrow derived haematopoetic cells playing a crucial role not only in immune response but also in the tumor microenvironment with protumorigenic and antitumorigenic functions. The role of MC in primary cutaneous T-cell lymphomas (
Johanna Eder, Radu Rogojanu, Waltraud Jerney, Friedrich Erhart, Alexander Dohnal, Melitta Kitzwögerer, Georg Steiner, Julia Moser, Franz Trautinger   +8 more
doaj   +1 more source

Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma

OncoImmunology, 2020
Staphylococcus aureus and its toxins have been linked to disease progression and mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role in anti-cancer responses and high CD8+ T cell numbers in tumor lesions are
Edda Blümel, Shamaila Munir Ahmad, Claudia Nastasi, Andreas Willerslev-Olsen, Maria Gluud, Simon Fredholm, Tengpeng Hu, Bas G. J. Surewaard, Lise M. Lindahl, Hanne Fogh, Sergei B. Koralov, Lise Mette Rahbek Gjerdrum, Rachael A. Clark, Lars Iversen, Thorbjørn Krejsgaard, Charlotte Menné Bonefeld, Carsten Geisler, Jürgen C. Becker, Anders Woetmann, Mads Hald Andersen, Terkild Brink Buus, Niels Ødum   +21 more
doaj   +1 more source

Phase II evaluation of VDC-1101 in canine cutaneous T-cell lymphoma. [PDF]

, 2014
BackgroundCanine cutaneous T-cell lymphoma (CTCL) is an uncommon disease for which efficacious therapies are lacking. The novel anticancer nucleotide prodrug VDC-1101 (formerly known as GS-9219) has shown efficacy in dogs with multicentric lymphoma.
Burgess, KE, Burton, JH, Morges, MA, Saba, CF, Thamm, DH, Vail, DM   +5 more
core   +2 more sources

Cosmological Signature of New Parity-Violating Interactions [PDF]

, 1999
Does Nature yield any manifestations of parity violation other than those observed in weak interactions? A map of the cosmic microwave background (CMB) temperature and polarization will provide a new signature of P violation.
Kamionkowski, Marc, Lue, Arthur, Wang, Limin   +2 more
core   +2 more sources

Treating cutaneous T-cell lymphoma with highly irregular surfaces with photon irradiation using rice as tissue compensator. [PDF]

, 2015
PurposeCutaneous T-cell lymphoma (CTCL) is known to have an excellent response to radiotherapy, an important treatment modality for this disease.
Chakravarti, Arnab, Gupta, Nilendu, Hattie, Todd, Majithia, Lonika, Porcu, Pierluigi, Rong, Yi, Siddiqui, Farzan, Weldon, Michael, Wong, Henry K, Xu-Welliver, Meng   +9 more
core   +2 more sources

Antibiotics can improve CTCL [PDF]

Blood, 2019
In this issue of Blood, Lindahl et al report that aggressive antibiotic treatment inhibits disease activity and lymphocyte proliferation in cutaneous T-cell lymphoma (CTCL).(1) These results are significant because they provide further evidence for a potential link between bacterial infection, activation of the immune system, and CTCL progression as ...
openaire   +3 more sources

Serum and cutaneous transcriptional expression levels of IL31 are minimal in cutaneous T cell lymphoma variants

Biochemistry and Biophysics Reports, 2021
Aim: Recent studies suggested a role for IL31 in the pathogenesis of pruritus and disease severity in patients with cutaneous T cell lymphomas (CTCL). However, discrepant results were reported for IL31 serum levels, transcriptional expression levels or ...
S. van Santen, J.J. Out, W.H. Zoutman, K.D. Quint, R. Willemze, M.H. Vermeer, C.P. Tensen   +6 more
doaj   +1 more source

Impedance of a sphere oscillating in an elastic medium with and without slip [PDF]

, 2006
The dynamic impedance of a sphere oscillating in an elastic medium is considered. Oestreicher's formula for the impedance of a sphere bonded to the surrounding medium can be expressed simply in terms of three lumped impedances associated with the ...
Abramowitz M., Andrew N. Norris, Stokes G. G., von Gierke H. E.   +3 more
core   +6 more sources