Results 21 to 30 of about 11,382 (203)
Frontiers in Genetics, 2022 Cutaneous T-cell lymphomas (CTCLs) are a subset of T-cell malignancies presenting in the skin. The treatment options for CTCL, in particular in advanced stages, are limited.
Eliza Mari Kwesi-Maliepaard +8 more
doaj +1 more source
Loss of the candidate tumor suppressor ZEB1 (TCF8, ZFHX1A) in Sézary syndrome [PDF]
, 2018 Cutaneous T-cell lymphoma is a group of incurable extranodal non-Hodgkin lymphomas that develop from the skin-homing CD4+ T cell. Mycosis fungoides and Sézary syndrome are the most common histological subtypes.
Benucci, Roberto +9 more
core +2 more sources
Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma
Frontiers in Immunology, 2023 Cutaneous 5T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a challenging disease to diagnose and treat due to disease heterogeneity, treatment resistance, and lack of effective ...
Mitchell N. Lefebvre +9 more
doaj +1 more source
Transcript-indexed ATAC-seq for precision immune profiling. [PDF]
, 2018 T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding
Buenrostro, Jason D +21 more
core +1 more source
Erythematous Macular Eruption in an Older Woman [PDF]
, 2019 A white woman in her 70s with advanced Alzheimer disease was referred to the hematology clinic for evaluation of a high hemoglobin level (169 g/L; normal range, 120-160 g/L) and red blood cell count (5.67 × 1012/L; normal range, 3.8-4.8 × 1012/L) as well
Kernohan, Neil +2 more
core +2 more sources
Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides [PDF]
, 2012 Copyright @ 2012 John Wiley & SonsThe miRNA expression profiles of skin biopsies from 14 primary cutaneous anaplastic large cell lymphoma (C-ALCL) patients were analysed with miRNA microarrays using the same control group of 12 benign inflammatory ...
Ballabio, E +7 more
core +1 more source
Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions
JID Innovations, 2022 Cutaneous T-cell lymphoma (CTCL) is a life-debilitating malignancy of lymphocytes homing to the skin. Although CTCL is thought to arise from a combination of genetic, epigenetic, and environmental factors, specific triggers are unclear.
Carina A. Dehner +7 more
doaj +1 more source
Tensor Contraction Layers for Parsimonious Deep Nets [PDF]
, 2017 Tensors offer a natural representation for many kinds of data frequently encountered in machine learning. Images, for example, are naturally represented as third order tensors, where the modes correspond to height, width, and channels. Tensor methods are
Anandkumar, Anima +4 more
core +2 more sources
Brentuximab Beats Standard Therapies for CTCL [PDF]
Cancer Discovery, 2017 Abstract Compared with a physician's choice of either methotrexate or bexarotene, the CD30-directed antibody–drug conjugate brentuximab vedotin led to significantly superior clinical responses in patients with cutaneous T-cell lymphomas, according to the results of the international phase III ALCANZA trial.
openaire +2 more sources
Frontiers in Immunology, 2021 In cutaneous T-cell lymphoma (CTCL), which arises from skin-tropic memory T cells, malignant T cells and benign T cells are confined in the same skin lesions.
Miki Kume +13 more
doaj +1 more source