Results 91 to 100 of about 146,534 (333)

EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

Exploration, EarlyView.
ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation of tumor cells, which share similarities with cystic epithelial cells in ADPKD. This study
Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang   +15 more
wiley   +1 more source

The clinical value of KL-6 for predicting the occurrence and severity of connective tissue disease-associated interstitial lung disease is not affected by CTD type or treatment [PDF]

PeerJ
Objective The aim of this study was to explore the potential values of Krebs von den Lungen-6 (KL-6), neutrophil to lymphocyte ratio (NLR), systemic immune inflammation (SII), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR) and red
Huifang Xing, Hongping Liang
doaj   +2 more sources

Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification

iMetaOmics, EarlyView.
We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N‐terminal regions, repeat sequences, and sequences motifs. We developed an AI‐driven algorithm, Cas12fam, which allows precise annotation of 18 distinct domains in Cas12 proteins.
Meixia Yu, Zilong Zhao, Peiyang Li, Yunpeng Teng, Feng Xu, Zhimeng Li, Zhijia Yang, Hainan Zhao, Huanbin Zhou, Lanqin Xia, Jinsheng Lai, Beibei Xin   +11 more
wiley   +1 more source

Colorectal Perforation in Patients with Connective Tissue Disease

Emergency Medicine International, 2019
Purpose. The goal of this retrospective study was to identify prognostic factors associated with mortality after surgery for colorectal perforation among patients with connective tissue disease (CTD) and to review postoperative outcomes based on these ...
Kiichi Sugimoto, Kazuhiro Sakamoto, Yu Okazawa, Rina Takahashi, Kosuke Mizukoshi, Hisashi Ro, Masaya Kawai, Shingo Kawano, Shinya Munakata, Shun Ishiyama, Hirohiko Kamiyama, Makoto Takahashi, Yutaka Kojima, Yuichi Tomiki, Naoto Tamura   +14 more
doaj   +1 more source

The evolutionary landscape and serotypic dynamics of avian infectious bronchitis virus from spike protein

iMetaOmics, EarlyView.
This study integrates two decades of surveillance with genomic and structural analyses to decipher how spike protein glycosylation haplotypes drive avian coronavirus evolution. We uncover how specific glycosylation patterns associate with receptor‐binding affinity, shape global transmission dynamics, and correlate with clinical outcomes.
Hao Zhang, Zongxi Han, Chuangchao Zou, Yihui Huang, Shiping Sun, Ouyang Peng, Usama Ashraf, Qiuping Xu, Yao Ge, Qixiang Kang, Xiuli Ma, Xinheng Zhang, Ye Zhao, Xin Yang, Hongning Wang, Guozhong Zhang, Qingmei Xie, Mang Shi, Yongsen Ruan, Min Liao, Shengwang Liu, Yongchang Cao   +21 more
wiley   +1 more source

Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription

Nature Communications
The C-terminal domain of RPB1 (CTD) orchestrates transcription by recruiting regulators to RNA Pol II upon phosphorylation. With CTD driving condensate formation on gene loci, the molecular mechanism behind how CTD-mediated recruitment of transcriptional
Qian Zhang, Wantae Kim, Svetlana B. Panina, Joshua E. Mayfield, Bede Portz, Y. Jessie Zhang   +5 more
doaj   +1 more source

OP0013 APPLYING STANDARD CLASSIFICATION CRITERIA EXCLUDES UP TO A HALF OF ALL PATIENTS FROM CONNECTIVE TISSUE DISEASES (CTD) CLINICAL TRIALS [PDF]

, 2023
Sarah Dyball, Mia Rodziewicz, Anastasia‐Vasiliki Madenidou, John A. Reynolds, Ariane L. Herrick, S. Haque, Hector Chinoy, Ellen Bruce, Ben Parker, Ian N Bruce   +9 more
openalex   +1 more source

Genome‐wide association study of periodontitis severity and progression

Journal of Periodontology, EarlyView.
Abstract Background To add to the knowledge base of periodontal genomics, we carried out a genome‐wide association study (GWAS) of periodontitis severity and progression among 416 mixed‐ethnicity adult participants of a periodontitis clinical study. Methods Participants were 168 adults (mean age = 50 years, 46% males) with severe periodontitis and 248 ...
Flavia Teles, Ganesh Chandrasekaran, Lynn Martin, Poojan Shrestha, Kevin Moss, Michele Patel, Michael J. Kallan, Camila Furquim, Andrew J. Cucchiara, James D. Beck, Kari E. North, Joseph Glessner, Kimon Divaris   +12 more
wiley   +1 more source

A review on the C-terminal domain of channel protein with necrosis-inducing toxin as a novel necrotizing toxin of Mycobacterium tuberculosis

Biomedical and Biotechnology Research Journal, 2018
Tuberculosis is a highly infectious illness that has been considered a worldwide health danger. Existence inside macrophages is a main characteristic of Mycobacterium tuberculosis virulence and essential to make a perdurable infection in the human body ...
Poopak Farnia, Tayebeh Farhadi, Parissa Farnia, Jalaledin Ghanavi, Ali Akbar Velayati   +4 more
doaj   +1 more source

CTD Standard Sensors.

, 2017
CalCOFI's primary hydrographic instrument is a Seabird 911+ CTD equipped with dual temperature, conductivity and oxygen sensors mounted on a 24-10L bottle rosette. Additional CTD sensors mounted on the rosette frame include a fluorometer, transmissometer, nitrate sensor, PAR, pH and altimeter. The CTD-Rosette is lowered into the ocean measuring a suite
openaire   +2 more sources