Results 141 to 150 of about 146,534 (333)

Mutant p53 Regulates Pyruvate Dehydrogenase Kinase 1 (PDK1) to Promote Proliferation and Migration in Breast Cancer

Cancer Science, EarlyView.
PDK1 is a direct transcriptional repression target of wtp53 and mutp53 can sustain its own stability by upregulating PDK1 in breast cancer. ABSTRACT Tumor suppressor p53 is the most frequently mutated gene in cancers. Mutations in p53 not only result in the loss of its classical tumor‐suppressive functions but also confer new oncogenic properties.
Yan Ye, Zuli Ou, Canling Li, Qingyu Liao, Qian Zeng, Xiaoqian Ju, Dian Zhang, Yu Wei, Xiang Zhang, Tao Zhang, Kejia Wu   +10 more
wiley   +1 more source

Challenges Faced During eCTD and CTD Filling Procedures for USFDA and Canada

, 2019
Nisar Ahammad, Nagarjuna Reddy, M. Nagabhushanam, Brahmaiah Ramakrishna   +3 more
openalex   +2 more sources

Prevalence and Spectrum of Congenital Heart Disease in Individuals With Distal Chromosome 22q11.22–23 Deletions

Clinical Genetics, EarlyView.
The frequency and severity of congenital heart disease vary extensively in individuals with 22q11.22–23 distal deletions. Reduced gene dosage particularly within the low copy repeat (LCR22) D–E region including MAPK1 and HIC2 conveys risk for these defects.
Tanner J. Nelson, Daniel E. McGinn, T. Blaine Crowley, Lydia Rockart, Audrey Green, Victoria Giunta, Oanh Tran, Daniella Miller, Jeroen Breckpot, Ann Swillen, M. Cristina Digilio, Marta Unolt, Carolina Putotto, Federica Pulvirenti, Bruno Marino, Beverly S. Emanuel, Elaine H. Zackai, Zhengdong D. Zhang, Elizabeth Goldmuntz, Erik Boot, Anne S. Bassett, Bernice E. Morrow, Donna M. McDonald‐McGinn   +22 more
wiley   +1 more source

Investigating the Rules and Regulations of the Registration Process of Pharmaceutical Products in the Common Wealth of Independent States (CIS) in Comparison to Those in Iran

Journal of Pharmacoeconomics and Pharmaceutical Management
Background: Drug Dossier is a file document submitted based on the requirement of the drug approval process. It is a comprehensive scientific document used to obtained worldwide licensing approval of a drug by diverse health authorities.
Mostafa Khajeh Dehaghani, Abbas Kebriaee zadeh, Akbar Abdollahi-Asl   +2 more
doaj  

Rethinking Strategies for a Pharmaceutical Approach to Pain Related to Connective Tissue-Related Raynaud Phenomenon in the United States. [PDF]

Arthritis Care Res (Hoboken)
Objective There are no US Food and Drug Administration–approved therapies for Raynaud phenomenon (RP) in the United States. Clinical trials have been challenged by study design. Important advances in RP patient‐reported outcome measures and mechanistic quantification allow RP‐related pain characterization.
Frech TM, Frech CG, Merryman WD, Sternlicht A, Baba J.   +4 more
europepmc   +2 more sources

CDK12 Inactivation Attenuates Prostate Cancer Progression by Inhibiting BNIP3‐Mediated Mitophagy

Cell Proliferation, EarlyView.
In response to enzalutamide, damaged mitochondria are targeted for mitophagic degradation through the binding of BNIP3 to LC3, forming autophagosomes that are subsequently transported to lysosomes for degradation. These self‐protective mechanisms promote mitochondrial renewal, reduce oxidative stress and finally contribute to cancer cell survival ...
Mengjun Huang, Hanqi Lei, Tongyu Tong, Hailin Zou, Binyuan Yan, Fei Cao, Yiting Wang, Qiliang Teng, Bin Xu, Juan Luo, Yupeng Guan, Shaohong Lai, Peng Li, Jun Pang   +13 more
wiley   +1 more source

Transcription Factor TCF12‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation

Cell Proliferation, EarlyView.
Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao, Chi Zhang, Zuo‐Qi Deng, Yue‐xin Qiu, Zhao Zhang, Heng‐Yu Fan, Jing Li, Hong‐Bo Wu   +7 more
wiley   +1 more source

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

The FEBS Journal, EarlyView.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska, Anna Koczurowska, Marta Orlikowska, Maciej Nielipinski, Dominika Nielipinska, Bartosz Sekula   +5 more
wiley   +1 more source

SARS‐CoV‐2 nucleocapsid protein variants have differential RNA chaperone activity

The FEBS Journal, EarlyView.
The SARS‐CoV‐2 nucleocapsid (N) protein facilitates RNA annealing through its RBD–IDR2–CTD region, identifying it as a functional RNA chaperone. The Omicron BA.5 variant shows reduced chaperone activity compared to the Wuhan wild‐type protein. Although phosphorylation has no effect on wild‐type N, phosphomimetic modification of BA.5 N restores its RNA ...
Sabrina Babl, Julia M. Seidel, Fabian Kugler, Elisabeth Silberhorn, Anna Ludwig, Jonas Abel, Sophia Winklbauer, Niklas Schaub, Silvia Materna‐Reichelt, Kamran Honarnejad, Nataša Stojanović Gužvić, Gernot Längst   +11 more
wiley   +1 more source