Results 151 to 160 of about 147,964 (338)

GCN2 in proteostasis: structural logic, signalling networks and disease

open access: yesThe FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

open access: yesThe FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak   +7 more
wiley   +1 more source

KU80 suppresses endonuclease G activity to preserve genomic integrity

open access: yesThe FEBS Journal, EarlyView.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan   +8 more
wiley   +1 more source

Technical Note: Animal-borne CTD-Satellite Relay Data Loggers for real-time oceanographic data collection [PDF]

open access: gold, 2009
Lars Boehme   +7 more
openalex   +1 more source

Decadal Rapid Change in Energetic Carrying Capacity for Juvenile Chum Salmon in the Sanriku Coast

open access: yesFisheries Oceanography, EarlyView.
ABSTRACT Adult returns to coastal rivers in Sanriku, located near the southernmost area of chum salmon distribution, have declined since 2010. Climate‐induced fluctuations in juvenile prey availability may affect growth and survival, which are linked to adult returns.
Yuki Iino   +3 more
wiley   +1 more source

Quantitative CT analysis in interstitial pneumonia with autoimmune features: diagnostic and prognostic insights from a retrospective cohort study. [PDF]

open access: yesInsights Imaging
Pušeljić M   +6 more
europepmc   +1 more source

Dissolved Nutrients (NO3, NO2, NH4, Si, PO4) matched with TMR CTD Data

open access: green
Meyer, Annaliese   +4 more
openalex   +1 more source

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