GCN2 in proteostasis: structural logic, signalling networks and disease
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Physical oceanography around Spitsbergen in 1993 from CTD SVALB1993_18
Shuki Ushio
openalex +1 more source
The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
wiley +1 more source
Physical oceanography from SeaSoar CTD DI192_TR05.2112
Kelvin J Richards
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RETRACTED: Connective tissue disease-related interstitial lung disease (CTD-ILD) and interstitial lung abnormality (ILA): Evolving concept of CT findings, pathology and management [PDF]
Hongseok Yoo +7 more
openalex +1 more source
KU80 suppresses endonuclease G activity to preserve genomic integrity
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan +8 more
wiley +1 more source
Technical Note: Animal-borne CTD-Satellite Relay Data Loggers for real-time oceanographic data collection [PDF]
Lars Boehme +7 more
openalex +1 more source
Decadal Rapid Change in Energetic Carrying Capacity for Juvenile Chum Salmon in the Sanriku Coast
ABSTRACT Adult returns to coastal rivers in Sanriku, located near the southernmost area of chum salmon distribution, have declined since 2010. Climate‐induced fluctuations in juvenile prey availability may affect growth and survival, which are linked to adult returns.
Yuki Iino +3 more
wiley +1 more source
Quantitative CT analysis in interstitial pneumonia with autoimmune features: diagnostic and prognostic insights from a retrospective cohort study. [PDF]
Pušeljić M +6 more
europepmc +1 more source
Dissolved Nutrients (NO3, NO2, NH4, Si, PO4) matched with TMR CTD Data
Meyer, Annaliese +4 more
openalex +1 more source

