Artificial intelligence streamlines scientific discovery of drug–target interactions
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley +1 more source
Cor Triatriatum Dexter: The Largest Comprehensive Review in the Field on 124 Worldwide Cases (1968-Now). [PDF]
Bassareo PP +7 more
europepmc +1 more source
Circulation and Variability in the Tropical Atlantic, METEOR-Bericht Cruise No. 68, Leg 2 from Recife, Brazil to Mindelo, Cape Verde June 6 to July 9, 2006 [PDF]
Beckmann, Uwe +24 more
core
Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So +7 more
wiley +1 more source
Cargo Recognition of Nesprin-2 by the Dynein Adapter Bicaudal D2 for a Nuclear Positioning Pathway That Is Important for Brain Development. [PDF]
Rodriguez Castro ED +7 more
europepmc +1 more source
Methane concentration of the water column at CTD station SO178-73-1, Okhotsk Sea
Wolf Christian Dullo +2 more
openalex +1 more source
Internal Lee Waves Control Deep Ocean Turbulent Mixing in the Antarctic Circumpolar Current at 50°E
Abstract Full‐depth (Surface‐to‐bottom) turbulent kinetic energy dissipation (TKED) observed with fast‐response thermistors across the Antarctic Circumpolar Current (ACC) at 50° $\mathit{{}^{\circ}}$E is compared with the energy flux of bottom‐generated internal waves estimated with high‐resolution multibeam bathymetry.
Yusuke Sasaki, Ichiro Yasuda
wiley +1 more source
A bacterial translation activator with an intrinsically disordered RNA-binding region. [PDF]
Basu P +4 more
europepmc +1 more source

