Results 241 to 250 of about 147,964 (338)

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, Volume 13, Issue 13, 3 March 2026.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

The Allosteric Regulation of the DNA-Binding Domain of p53 by the Intrinsically Disordered C-Terminal Domain. [PDF]

Pharmaceuticals (Basel)
Ning S, Zeng C, Wang H, Zhang J, Xue Y, Zhao Y.   +5 more
europepmc   +1 more source

Dissolved inorganic carbon, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments from POLARSTERN in the South Atlantic Ocean and Southern Oceans from 1998-03-28 to 1998-05-23 (NCEI Accession 0113595)

, 2013
Mario Hoppema, R. BELLERBY, E. FAHRBACH
openalex   +1 more source

Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease

Arthritis &Rheumatology, Volume 78, Issue 3, Page 566-581, March 2026.
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman, Voon Ong, Christopher P. Denton   +2 more
wiley   +1 more source

Connective Tissue Disease-Associated Pulmonary Arterial Hypertension: Current Therapeutic Strategies and Future Prospects. [PDF]

Biomolecules
Yokoyama YM, Watanabe R, Yamaguchi T, Ishihara R, Shiomi M, Fujita Y, Katsushima M, Fukumoto K, Haji Y, Yamada S, Hashimoto M.   +10 more
europepmc   +1 more source

Size of planktic foraminifera at CTD station PS55/066

, 2001
Elena Stangeew
openalex   +1 more source

North Atlantic 2001 - Part 3 Cruise No. 50, Leg 3 20 June – 15 July 2001, St. John’s – Reykjavik J. Holfort, [PDF]

, 2002
Bulsiewicz, K., Hargreaves, G., Holfort, J., Hüttemann, S., Kahl, G., Kirch, Anja, Kirchner, K., Moll, A., Quast, G., Read, J., Rellensmann, F., Rudels, B., Schulze, K., Sommer, V., Truscheit, T., Verch, N., Welsch, A.   +16 more
core  

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source

Effectiveness of thiazide diuretics in patients with hypertension: a systematic review and meta-analysis. [PDF]

Ann Med Surg (Lond)
Ashraf T, Chandni F, Nancy F, Devi N, Bai D, Waseem R, Jabbar M, Turesh M, Dev S, Zafar RBI, Manan S, Jabbar F, Maryam I, Naveed Z, Jawad S.   +14 more
europepmc   +1 more source

Hypereosinophilia Associated With Antisynthetase Syndrome With Anti‐Ro52/PL12 Co‐Positivity: An Unusual Presentation

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Hypereosinophilia is uncommon in ASS and this presentation makes diagnosis more challenging. Anti‐PL12's role in the severity of ILD is controversial but its association with anti‐Ro52 seems to give a more serious disease phenotype. African ethnicity could be a negative prognostic factor, associated with lung disease severity.
Abeline Kapuczinski, Marc Léon, Camelia Rossi, Benjamin Bondue, Nathalie Demeulenaere   +4 more
wiley   +1 more source