Results 281 to 290 of about 147,964 (338)

Metagenomic mining reveals novel Cas12 subtypes and their evolutionary diversification

iMetaOmics, Volume 3, Issue 1, March 2026.
We identified 4112 Cas12 Proteins and 6 new Cas12 subtypes, revealed their significant diversity in N‐terminal regions, repeat sequences, and sequences motifs. We developed an AI‐driven algorithm, Cas12fam, which allows precise annotation of 18 distinct domains in Cas12 proteins.
Meixia Yu, Zilong Zhao, Peiyang Li, Yunpeng Teng, Feng Xu, Zhimeng Li, Zhijia Yang, Hainan Zhao, Huanbin Zhou, Lanqin Xia, Jinsheng Lai, Beibei Xin   +11 more
wiley   +1 more source

Screening and characterization of monoclonal antibodies with neutralizing activity against porcine transmissible gastroenteritis virus. [PDF]

BMC Vet Res
Jia H, Song T, Zheng B, Wang X, Rui P, Yan S, Liu W, Ma Z.   +7 more
europepmc   +1 more source

Single‐cell multi‐omics analysis of the tumour microenvironment for colorectal cancer liver metastasis

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Jiao Guan, Mingwei Guo, Min Hu, Shilin Wu, Jin Qiu, Xinran Ma, Yingying Guo, Haibing Chen, Zunqiang Zhou   +8 more
wiley   +1 more source

The evolutionary landscape and serotypic dynamics of avian infectious bronchitis virus from spike protein

iMetaOmics, Volume 3, Issue 1, March 2026.
This study integrates two decades of surveillance with genomic and structural analyses to decipher how spike protein glycosylation haplotypes drive avian coronavirus evolution. We uncover how specific glycosylation patterns associate with receptor‐binding affinity, shape global transmission dynamics, and correlate with clinical outcomes.
Hao Zhang, Zongxi Han, Chuangchao Zou, Yihui Huang, Shiping Sun, Ouyang Peng, Usama Ashraf, Qiuping Xu, Yao Ge, Qixiang Kang, Xiuli Ma, Xinheng Zhang, Ye Zhao, Xin Yang, Hongning Wang, Guozhong Zhang, Qingmei Xie, Mang Shi, Yongsen Ruan, Min Liao, Shengwang Liu, Yongchang Cao   +21 more
wiley   +1 more source

Structures of <i>Vibrio cholerae</i> transcription complexes reveal how ToxR and TcpP recruit the RNA polymerase and activate virulence genes. [PDF]

Sci Adv
Alcaide-Jiménez A, Canals A, Baudin F, Machón C, Fàbrega-Ferrer M, Bantysh O, Pérez-Luque R, Murciano B, Mohammad AA, Rowse MJ, Ferracciolo JM, Krukonis ES, Müller CW, Coll M.   +13 more
europepmc   +1 more source

Hesperidin Attenuates H₂O₂‐Induced Neurotoxicity via Modulation of Inflammatory Pathways and MMP Activity in Differentiated SH‐SY5Y Cells: In Vitro and In Silico Models

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 3, March 2026.
Hesperidin protects differentiated SH‐SY5Y cells from H₂O₂‐induced neurotoxicity by reducing oxidative stress and suppressing pro‐inflammatory cytokines. It further inhibits NF‐κB/COX‐2 signaling and downregulates MMP‐2/MMP‐9 activity. In vitro findings are supported by in silico analyses showing strong binding to inflammatory targets. ABSTRACT Chronic
Hamiyet Eciroglu‐Sarban, Fatma Yildiz, Fatma Gonca Kocanci, Pinar Altin‐Celik, Muazzez Derya‐Andeden   +4 more
wiley   +1 more source

Optimizing Gene Therapies for Creatine Transporter Deficiency: Correcting by Connecting. [PDF]

Epilepsy Curr
Lillis KP.
europepmc   +1 more source

Southern Surveyor voyage SS2010_v06 CTD data

, 2011
Charitha; id_orcid 0000-0003-2229-6183 Pattiaratchi, Hiski Kippo, Oceans Institute, School of Engineering   +3 more
openalex   +1 more source

Westerly winds prompted an anomalous southward migration of Pacific saury (Cololabis saira)

Limnology and Oceanography Letters, Volume 11, Issue 2, March 2026.
Abstract The Pacific saury (Cololabis saira), a key pelagic fish in the Northwest Pacific, exhibits autumn migration modulated by Kuroshio–Oyashio Extension mesoscale features, yet daily fishing ground variability remains unexplained. Traditional reliance on remote sensing data has limited understanding of the three‐dimensional mechanisms governing the
Yulei Zhang, Ruichen Zhu, Jianchao Li, Zhaohui Chen, Hao Tian, Yang Liu, Peng Sun, Zhenjiang Ye, Yongjun Tian   +8 more
wiley   +1 more source