Results 51 to 60 of about 146,534 (333)

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Physical oceanography [PDF]

, 1992
The physical oceanography component of the AMLR program provides information on the hydrography of the upper water column with the objective of assessing its influence on the observed distribution of krill (Euphausia superba).
Amos, Anthony F., Heimann, J. K., Lavender, Margaret   +2 more
core   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

123I-FP-CIT SPECT imaging in early diagnosis of dementia in patients with and without a vascular component

Frontiers in Systems Neuroscience, 2015
Alzheimer’s disease (AD) and vascular dementia (VaD) are the most common cause of dementia. Cerebral ischemia is a major risk factor for development of dementia.
Marina eGarriga, Marta eMila, Manzoor eMir, Raid eAl-Baradie, Sonia eHuertas, Cesar eCastejon, Dolores eBadenas, Laura eCasas, Nuria eGimenez, M.Angels eFont, Jose M eGonzalez, Maria eYsamat, Miquel eAguilar, Mark eSlevin, Jerzy eKrupinski   +14 more
doaj   +1 more source

Targeted treatment strategy for patients with severe pulmonary hypertension secondary to connective tissue diseases

Rheumatology & Autoimmunity, 2023
Background Pulmonary arterial hypertension (PAH) associated with connective tissue diseases (CTD) (CTD‐PAH) remains a difficult challenge in clinical practice.
Bo Jiang, Chun Wang, Yansheng Jin, Guanjun Guo, Kangxing Zhou, Xuebing Feng, Genhong Yao   +6 more
doaj   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

TEACHING LOAD IN THE LIGHT OF INTERNATIONAL EXPERIENCE

Высшее образование в России, 2016
The article considers the factors promoting development of Russian universities in various areas such as improving the educational activity efficiency, development of research, the use of distance learning (MOOC), the formation of required competences of
Dmitriy Yu. Raychuk
doaj  

A Mini‐Spidroin Forms High‐Performance Artificial Spider Silk via Edge‐Cysteine–Locked β‐Sheet Assembly

Advanced Science, EarlyView.
Cysteine‐engineered mini‐spidroins (∼33 kDa) undergo phosphate‐induced liquid–liquid phase separation (LLPS), where disulfide bonds lock partially aligned polyA segments. Subsequent microfluidic spinning promotes directional β‐sheet crystallization, producing fibers with 531 MPa strength and 182 MJ/m3 toughness.
Min Li, Huan Chen, Qi Zhang, Xiaoyun Xu, Yini Zheng, Chunyu Lyu, Weibin Jia, Jun Fan, Fu‐Rong Chen, Wei Liu, Jinlian Hu   +10 more
wiley   +1 more source

HYDRAULIC DEVELOPMENT OF A CENTRIFUGAL PUMP IMPELLER USING THE AGILE TURBOMACHINERY DESIGN SYSTEM

TASK Quarterly, 2002
The impeller of an existing industrial pump (with both geometry and performance known) was analyzed and redesigned using an integrated, design/analysis, turbomachinery geometry modeling and flow simulation system.
KRZYSZTOF DENUS, COLIN OSBORNE
doaj  

Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II

Nature Communications, 2023
Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered sequence, the CTD enables clustering and phase separation of Pol II.
David Flores-Solis, Irina P. Lushpinskaia, Anton A. Polyansky, Arya Changiarath, Marc Boehning, Milana Mirkovic, James Walshe, Lisa M. Pietrek, Patrick Cramer, Lukas S. Stelzl, Bojan Zagrovic, Markus Zweckstetter   +11 more
doaj   +1 more source