Results 81 to 90 of about 146,534 (333)

UHPLC‐MSE Insights Into Extrusion‐Driven Changes in Wheat Phenolics and Their Bioaccessibility

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives This study evaluated the impact of thermoplastic extrusion (wheat snack, WS) and cold extrusion followed by cooking (wheat pasta, WP) on phenolic compounds (PC) in two Brazilian wheat genotypes, commercially classified by gluten strength (ORS Agile, strong; ORS Vintecinco, weak).
Renata Marenda Ferreira, Carolina Thomaz Dos Santos D'Almeida, Thais Oliveira de Alves, Carlos Wanderlei Piler de Carvalho, Cristina Yoshie Takeiti, Mariana Simões Larraz Ferreira   +5 more
wiley   +1 more source

Carpal Tunel Syndrome

JKS (Jurnal Kedokteran Syiah Kuala), 2014
Abstrak. Carpal Tunnel Syndrome (CTS) merupakan salah satu penyakit yang sering terjadi pada pekerja industri. The National Institute for Occupational Safety and Health (NIOSH) tahun 1990 memperkirakan 15-20% pekerja Amerika Serikat berisiko menderita ...
Liza Salawati, Syahrul Syahrul
doaj  

CTD System.

, 2017
A Sea-Bird Electronics 911plus V2 CTD collects vertical profile data at every CalCOFI station. In addition to being a dual TCO (temperature, conductivity, and oxygen) system, the CTD also interfaces with a transmissometer, fluorometer, PAR/SPAR meters, altimeter, nitrate, and pH sensor.
openaire   +2 more sources

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Information technologies as a tool of pharmaceutical data management

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article analyses international experience of information technology use in pharmaceutical data management. It investigates the possibility of using CALS/PLM-technologies for IT-based management of pharmacy-related activities as exemplified by the ...
K. A. Koshechkin, E. M. Rychikhina
doaj  

Diagnostic Efficacy of Quantitative Computed Tomography in CTD-ILA/ILD

CT Lilun yu yingyong yanjiu
Objective: The aim of this study is to evaluate the diagnostic efficacy of quantitative computed tomography (CT) in differentiating between connective tissue disease-associated interstitial lung abnormalities (CTD-ILA) and connective tissue disease ...
Ke WANG, Hanying JI, Xiaoqi HUANG, Juan PAN   +3 more
doaj   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Connective tissue disease related interstitial lung diseases and idiopathic pulmonary fibrosis: provisional core sets of domains and instruments for use in clinical trials [PDF]

, 2013
Rationale Clinical trial design in interstitial lung diseases (ILDs) has been hampered by lack of consensus on appropriate outcome measures for reliably assessing treatment response.
Antoniou, K, Baughman, RP, Brown, KK, Castelino, FV, Christmann, RB, Christopher-Stine, L, Collard, HR, Cottin, V, Danoff, S, Dellaripa, PF, Denton, CP, Distler, O, Fischer, A, Flaherty, KR, Frankel, S, Highland, KB, Hummers, L, Huscher, D, Khanna, D, Kim, DS, Kowal-Bielecka, OM, LeSage, D, Lynch, DA, Matteson, EL, Merkel, PA, Miller, FW, Mittoo, S, Oddis, CV, Phillips, K, Pittrow, D, Proudman, SM, Richeldi, L, Ryu, JH, Saketkoo, LA, Sandorfi, N, Sarver, C, Seibold, JR, Shah, AA, Strand, V, Swigris, J, Wells, AU   +40 more
core   +1 more source

Memantine treatment in individuals with GRIN gain‐of‐function variants is associated with improvements in behavior, development, and seizure frequency

Epilepsia, EarlyView.
Abstract Objective GRIN‐related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N‐methyl‐D‐aspartate receptor (NMDAR) function. Functional changes include gain (GoF) and loss of receptor function (LoF). Clinical reports describing the use of the NMDAR blocker memantine in GRIN‐related disorders
Maike Karnstedt, Riley E. Perszyk, Scott J. Myers, Ellington McDaniels, Marta Somorai, Ingo Borggraefe, Danielle C. M. Veenma, An‐Sofie Schoonjans, Pasquale Striano, Tadeu A. Fantaneanu, Steffen Syrbe, Kristen Park, Wenjuan Chen, Hongjie Yuan, Stephen F. Traynelis, Timothy A. Benke, Johannes R. Lemke, Ilona Krey   +17 more
wiley   +1 more source

The teneurin C-terminal domain possesses nuclease activity and is apoptogenic. [PDF]

, 2018
Teneurins are type 2 transmembrane proteins expressed by developing neurons during periods of synaptogenesis and apoptosis. Neurons expressing teneurin-1 synapse with other teneurin-1-expressing neurons, and neurons expressing teneurin-2 synapse with ...
Chiquet-Ehrismann, Ruth, Ferralli, Jacqueline, Tucker, Richard P   +2 more
core   +3 more sources