Results 111 to 120 of about 424,490 (383)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Exposure–response relationships for the ACGIH threshold limit value for hand-activity level: results from a pooled data study of carpal tunnel syndrome

Scandinavian Journal of Work, Environment & Health, 2014
OBJECTIVES: This paper aimed to quantify exposure–response relationships between the American Conference of Governmental Industrial Hygienists’ (ACGIH) threshold limit value (TLV) for hand-activity level (HAL) and incidence of carpal tunnel syndrome (CTS)
Jay M Kapellusch, Frederic E Gerr, Elizabeth J Malloy, Arun Garg, Carisa Harris-Adamson, Stephen S Bao, Susan E Burt, Ann Marie Dale, Ellen A Eisen, Bradley A Evanoff, Kurt T Hegmann, Barbara A Silverstein, Matthew S Theise, David M Rempel   +13 more
doaj   +1 more source

Educação CTS: parâmetros e propósitos brasileiros

, 2017
Neste artigo sao discutidos parâmetros e propositos da educacao ciencia-tecnologia-sociedade (CTS), presentes no contexto brasileiro do ensino de Ciencias.
Roseline Beatriz Strieder, M. D. Kawamura   +1 more
semanticscholar   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

An overview of the communications technology satellite project: Executive summary [PDF]

An overview of the Communications Technology Satellite (CTS) project, a joint venture between NASA and the Canadian Department of Communications is given.
Ogden, D., Rapp, W., Wright, D.
core   +1 more source

A PERSPECTIVA CTS NO ENSINO DE CIÊNCIAS

, 2022
Alex Antunes Mendes, Maykon Gonçalves Müller, Nelson Luiz Reyes Marques   +2 more
openalex   +2 more sources

Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement

Clinical & Translational Immunology, 2015
The manufacture of clinical grade cellular products for adoptive immunotherapy requires ex vivo culture and expansion of human T cells. One of the key components in manufacturing of T cell therapies is human serum (HS) or fetal bovine serum (FBS), which ...
Corey Smith, G. Økern, S. Rehan, L. Beagley, Sau K. Lee, T. Aarvak, K. Schjetne, R. Khanna   +7 more
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

The prevalence and incidence of carpal tunnel syndrome in US working populations

Scandinavian Journal of Work, Environment & Health, 2014
In the September issue of the Scandinavian Journal of Work, Environment and Health, Dale et al (1) estimated the prevalence and incidence of carpal tunnel syndrome (CTS) by pooling the raw individual-level data of six diverse prospective studies in US ...
Rahman Shiri
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source