Results 91 to 100 of about 24,746 (185)
Single‐cell transcriptomic analysis reveals APOE genotype‐dependent sex differences in Alzheimer's disease
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION
Alzheimer's disease (AD) is the most common form of dementia, with approximately two‐thirds of AD patients being female. Basic and clinical research studies provide strong evidence that sex‐specific differences contribute to AD complexity.Gefei Yu, Abigail Thorpe, Qi Zeng, Erming Wang, Alison Goate, Dongming Cai, Minghui Wang, Bin Zhang +7 morewiley +1 more sourceAlanine Aminotransferase Elevation at Diagnosis of Youth‐Onset Type 2 Diabetes: Prevalence, Predictors, and One‐Year Outcomes
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.A single‐centre retrospective review of youth‐onset Type 2 diabetes at diagnosis and one‐year follow‐up, showing a high prevalence of alanine aminotransferase (ALT) elevation at both time points. ALT elevation at diagnosis was associated with Hispanic ethnicity and lower HbA1C, but there was no clinically significant association between ALT elevation ...Sean DeLacey, Wenya Chen, Adesh Ranganna, Siyuan Feng, Mark Fishbein, Monica Bianco +5 morewiley +1 more sourceClinician Practices in Determining Expected Body Weights Across Eating Disorders: A Mixed Methods Study
European Eating Disorders Review, Volume 34, Issue 3, Page 584-598, May 2026.ABSTRACT Objective
Eating disorder (ED) treatment often involves establishing expected body weights (EBWs). While individualised approaches are commonly used, whether and how EBWs are set across EDs, clinician perspectives on different approaches, and clinician training in this practice remain poorly understood.Agatha A. Laboe, Molly F. Steinhoff, Siena S. Vendlinski, Anna Kreynin, Sarah Johnson‐Munguia, Ava Heyrman, Sophia Kreckler, Caitlyn Ruud, Katherine Schaumberg +8 morewiley +1 more sourceThe Proteo‐Transcriptome of Extracellular Vesicles and Particles Is Largely Preserved After Cryopreservation
Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.ABSTRACT
Extracellular vesicles and particles (EVPs) are small lipid‐bilayer membrane structures containing proteins, lipids, and nucleic acids that play crucial roles in tumorigenesis, metastasis, and immunomodulation. The extent to which frozen tissues faithfully reflect the biology of fresh tissues remains unclear.Yohei Nose, Diane Marie del Valle, Tina Ruth Gonsalves, Kevin Tuballes, Ethan Ellis, Hui Xie, Igor Figueiredo, Ruiwei Guo, Avni Chandra, Aana Hahn, Anish Korrapati, Giorgio Ioannou, Rafael Cabal, Swapnil Tichkule, John F. Fullard, Panos Roussos, Pedro Silva, Angelo Amabile, Jarod Morgenroth‐Rebin, Travis Dawson, Raphael Merand, Kai Nie, Zhihong Chen, Sharon Nirenberg, Brian Brown, Seunghee Kim‐Schulze, Andrew Kaufman, Raja Flores, Laura Zuluaga, Kristin Beaumont, Robert Sebra, Natasha Kyprianou, Kyrollis Attalla, Ketan Badani, Ash Tewari, Navneet Dogra, Sacha Gnjatic, Edgar Gonzalez‐Kozlova +37 morewiley +1 more sourceTranslation in action: Influence, collaboration, and evolution of COVID‐19 research with Clinical and Translational Science Awards consortium support
Clinical and Translational ScienceThe National Institutes of Health (NIH)'s Clinical and Translational Science Awards (CTSA) consortium aims to accelerate translational processes that move discoveries from bench to bedside.Nicole Llewellyn, Eric J. Nehl, Gaurav Dave, Deborah DiazGranados, David Flynn, Deborah Fournier, Verónica Hoyo, Clara Pelfrey, Shannon Casey +8 moredoaj +1 more sourceTrajectories of genetic risk across dimensions of alcohol use behaviors
Addiction, Volume 121, Issue 5, Page 1153-1165, May 2026.Abstract Background and aims
Alcohol use behaviors (AUBs) manifest in a variety of normative and problematic ways across the life course, all of which are heritable. Twin studies show that genetic influences on AUBs change across development, but this is usually not considered in research identifying and investigating the genes linked to AUBs ...Jeanne E. Savage, Fazil Aliev, Peter B. Barr, Maia Choi, Gabin Drouard, Megan E. Cooke, Sally I. Kuo, Mallory Stephenson, Sarah J. Brislin, Zoe E. Neale, Spit for Science Working Group, Karen Chartier, Ananda Amstadter, Danielle M. Dick, Emily Lilley, Renolda Gelzinis, Anne Morris, Katie Bountress, Amy E. Adkins, Nathaniel Thomas, Zoe Neale, Kimberly Pedersen, Thomas Bannard, Seung B. Cho, Peter Barr, Holly Byers, Erin C. Berenz, Erin Caraway, James S. Clifford, Megan Cooke, Elizabeth Do, Alexis C. Edwards, Neeru Goyal, Laura M. Hack, Lisa J. Halberstadt, Sage Hawn, Sally Kuo, Emily Lasko, Jennifer Lend, Mackenzie Lind, Elizabeth Long, Alexandra Martelli, Jacquelyn L. Meyers, Kerry Mitchell, Ashlee Moore, Arden Moscati, Aashir Nasim, Jill Opalesky, Cassie Overstreet, A. Christian Pais, Tarah Raldiris, Jessica Salvatore, Jeanne Savage, Rebecca Smith, David Sosnowski, Jinni Su, Chloe Walker, Marcie Walsh, Teresa Willoughby, Madison Woodroof, Jia Yan, Cuie Sun, Brandon Wormley, Brien Riley, Fazil Aliev, Roseann Peterson, Bradley T. Webb, COGA Investigators, Bernice Porjesz, Victor Hesselbrock, Arpana Agrawal, Danielle Dick, Howard J. Edenberg, Tatiana Foroud, Yunlong Liu, Martin H. Plawecki, Samuel Kuperman, Allan Anderson, Jacquelyn Meyers, Laura Bierut, Sarah Hartz, Marc Schuckit, Ronald Hart, Jay Tischfield, Laura Almasy, Alison Goate, Paul Slesinger, Denise Scott, Cathryn Holzhauer, Michie Hesselbrock, Dongbing Lai, John Nurnberger Jr., Leah Wetherill, Xiaoling Xuei, Sean O'Connor, John Kramer, Grace Chan, Chella Kamarajan, Ashwini Pandey, David B. Chorlian, Sivan Kinreich, Gayathri Pandey, Chris Chatzinakos, Jian Zhang, Stacey Saenz deViteri, Christian Richard, Arjun Bingly, Gita Pathak, Andrey Anokhin, Kathleen Bucholz, Fanghong Dong, Alexander Hatoum, Emma Johnson, Vivia McCutcheon, John Rice, Scott Saccone, Zhiping Pang, Sarah Brislin, Jennifer Moore, Alison Merikangas, Miri Gitik, Antti Latvala, Richard J. Rose, Jaakko Kaprio, Danielle M. Dick, Jacquelyn Meyers, Jessica E. Salvatore, Danielle Posthuma +127 morewiley +1 more sourceHepatic and abdominal adiposity in type 2 diabetes as assessed with machine learning on computed tomography scans
Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3742-3751, May 2026.Abstract Aims
The combined assessment of multiple abdominal imaging traits in relation to type 2 diabetes remains incompletely characterised. The study examines these relationships on computed tomography (CT) scans from a large‐scale, racially diverse, disease‐focused medical biobank.Richard H. Tran, Pavan Raghupathy, Mohamad Hazim, Elizabeth Thompson, Sophia Swago, Abhijit Bhattaru, Matthew MacLean, Jeffrey T. Duda, James Gee, Charles Kahn Jr., Daniel J. Rader, Arijitt Borthakur, Walter R. Witschey, Hersh Sagreiya +13 morewiley +1 more source