Results 31 to 40 of about 6,083,870 (296)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Pathogenesis and advances in immunotherapy for type 1 diabetes treatment

Biotechnology Reports
Type 1 diabetes (T1D) is an autoimmune disease marked by selective destruction of pancreatic β-cells, resulting in absolute insulin deficiency. Although insulin replacement remains the standard therapy, it does not address the underlying autoimmune ...
Tran Chi Linh, Nguyen Khanh Dung
doaj   +1 more source

Preparation and Antimicrobial Screeningof Cu (II), Ni (II), Zn (II) Cd (II) Complexes

E-Journal of Chemistry, 2006
The metal complexes of Ni(II), Cu(II), Zn(II) Cd(II) with organic ligands viz Hydrazine hydrate, 1,2-N,N'-Bisammonium thiocarbamoyl ethane and 1,4-N,N'-Bisammonium thiocarbamoyl benzene have been prepared.
R. M. Desai, M. K. Shah, V. H. Shah
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1

Scientific Reports, 2016
Cu(II)ATSM was developed as a hypoxia sensitive positron emission tomography agent. Recent reports have highlighted the neuroprotective properties of Cu(II)ATSM, yet there are no reports that it confers cardioprotection.
Salil Srivastava, Philip J. Blower, Aisah A. Aubdool, Robert C. Hider, Giovanni E. Mann, Richard C. Siow   +5 more
doaj   +1 more source

Toxicity of copper (II) metal complexes with amino acids ligands: A study of activity in Aedes aegypti larvae [PDF]

Anais da Academia Brasileira de Ciências
The larval control of Aedes aegypti has been done mainly by insecticides, which cause resistance and environmental contamination and have a high-cost development and application.
EDUARDO JOSÉ DE ARRUDA, CÍCERA MARIA DA SILVA, ALESSANDRA R. LIMA, GLENDA B. PORZANI, MONIZE M. DA SILVA, CLÁUDIO T. DE CARVALHO, ISAÍAS CABRINI, MAGDA F. FERNANDES   +7 more
doaj   +1 more source

Sintesis Karbon Aktif Limbah Lumpur Aktif Industri Gula sebagai Adsorben Limbah Logam Berat Cu(II)

Teknik, 2021
Penelitian ini bertujuan melakukan sintesis karbon aktif dari limbah lumpur aktif unit Sludge Drying Bed (SDB) industri gula sebagai adsorben dan efektifitasnya dalam menurunkan kandungan logam berat Cu(II).
Adhi Setiawan, Muhammad Iqbal Ali Bawafi, Tarikh Azis Ramadani, Indri Santiasih   +3 more
doaj   +1 more source