Results 61 to 70 of about 185,566 (265)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Longitudinal Study Examining Physical Activity Habit Formation

Behavioral Sciences
Habits are important factors that help guide the performance of health behaviours, yet little is known about how habits form following a major context change.
Thomas McAlpine, Caitlin Liddelow, Jessica Charlesworth, Enrique Mergelsberg, Astrid Green, Elizaveta Novoradovskaya, Teagan Franz, Darren Haywood, Frank D. Baughman, Hayley Breare, Barbara Mullan   +10 more
doaj   +1 more source

Role of Extrinsic Cues in the Formation of Quality Perceptions

Frontiers in Psychology, 2022
Examining the quality perceptions of consumers has often been recommended as an international research paradigm. This study is grounded in the Pakistani consumer market to evaluate the impact of food packaging cues on perceived product quality.
Anam Javeed, Anam Javeed, Mohammed Aljuaid, Zoya Khan, Zahid Mahmood, Duaa Shahid   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cue-based versus scheduled feeding for preterm infants transitioning from tube to oral feeding: the Cubs mixed-methods feasibility study

Health Technology Assessment, 2021
Background: There is a lack of evidence of the effect of cue-based feeding compared with scheduled feeding on important outcomes for preterm infants. Objectives: The objectives were as follows: (1) to describe the characteristics, components, theoretical
Alison McFadden, Bronagh Fitzpatrick, Shona Shinwell, Karen Tosh, Peter Donnan, Louise M Wallace, Emily Johnson, Steve MacGillivray, Anna Gavine, Albert Farre, Helen Mactier   +10 more
doaj   +1 more source

The Shading Cue in Context

i-Perception, 2010
The shading cue is supposed to be a major factor in monocular stereopsis. However, the hypothesis is hardly corroborated by available data. For instance, the conventional stimulus used in perception research, which involves a circular disk with monotonic luminance gradient on a uniform surround, is theoretically ‘explained’ by any quadric surface ...
Wagemans, Johan, Van Doorn, Andrea J., Koenderink, Jan   +2 more
openaire   +6 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Walking Turns in Parkinson's Disease Patients with Freezing of Gait: The Short-term Effects of Different Cueing Strategies

International Journal of Gerontology, 2016
Background: This study aimed to evaluate the effects of cueing on circular walking in patients with Parkinson's disease. Methods: Parkinson's disease patients in the “off” state were asked to walk on a designed route at their preferred speed.
Pei-Hao Chen, De-Jyun Liou, Kuang-Chung Liou, Jhih-Ling Liang, Shih-Jung Cheng, Jin-Siang Shaw   +5 more
doaj   +1 more source

A wolf in sheep's clothing: Predatory fish have convergent consumptive effects but divergent predation‐risk effects

Ecosphere, 2022
Although consumptive effects of predators have long been central to ecology, predation‐risk effects have emerged as major components of predator–prey interactions. Both consumptive and predation‐risk effects should vary with predator functional traits (e.
Jason R. Bohenek, Matthew R. Pintar, Tyler M. Breech, William J. Resetarits Jr   +3 more
doaj   +1 more source