Results 31 to 40 of about 1,682 (260)

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

open access: yesAdvanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen   +11 more
wiley   +1 more source

S’isoler pour honorer : l’exemple des sanctuaires de Déméter dans le Péloponnèse

open access: yesFrontière·s, 2020
Sanctuaries of Demeter in the Peloponnese are home to certain types of rituals, which nature often imposes concealment. Therefore, it is possible to determine the existence of several levels of borders protecting secret ceremonies. To install sanctuaries
Manon Sauvage‑Cerisier
doaj   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

open access: yesAdvanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong   +12 more
wiley   +1 more source

Book Review: E.D. Zilivinskaya. Architecture of the Golden Horde. Part 1. Cult Monuments. Moscow; Kazan: “Otechestvo” Publ., 2014. 228 p.,+ 220 p., ill.

open access: yesПоволжская археология, 2016
The reviewed monograph by E.D. Zilivinskaya is the fi rst fundamental research in the national historiography to address cult architecture of the Golden Horde.
Khuzin Fayaz Sh.
doaj  

Cult caves building on the territory of European Russia

open access: yesSamara Journal of Science, 2018
The paper deals with cult caves building on the territory of European Russia. The author draws attention to the fact that the process primarily depended on the nature of rock formation where the caves were constructed. In a softer and loose ground the walls and the ceiling were strengthened by armour stone or bricks after taking up the rocks. There was
openaire   +2 more sources

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

open access: yesAdvanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra   +23 more
wiley   +1 more source

Cults in Abruzzo’s small towns: S. Maria delle Grazie in Civitaretenga

open access: yesIn_Bo, 2017
The research aims to address, during the study days concerning the promotion and the future of religious buildings in the various local contexts, the cult of devotion in Abruzzo smaller towns, particularly in Civitaretenga. Navelli’s village, stands on a
Carlos Alberto Cacciavillani   +2 more
doaj   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

open access: yesAdvanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong   +13 more
wiley   +1 more source

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

open access: yesAngewandte Chemie, EarlyView.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno   +5 more
wiley   +2 more sources

A Quest for the Mechanism of Ultrahigh Resolution SEM Imaging

open access: yesAdvanced Science, EarlyView.
Using Monte Carlo simulations with explicit definitions of SE1 and SE2 align with a cascade secondary electron production model, this work shows that the 3D nanostructure modulated SE2 emission enhances other than to reduce topographical contrast via a “miniature Faraday cup” effect.
Hao Tian Chen   +3 more
wiley   +1 more source

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