Results 91 to 100 of about 134,511 (262)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

BRIDGES OF HEALTH: HOW EDUCATION, FAMILY, AND CULTURE SHAPE MIGRANT INTEGRATION IN THE CZECH REPUBLIC FROM A PUBLIC HEALTH PERSPECTIVE

Клінічна та профілактична медицина
Introduction. Migration is a multifaceted process that goes beyond physical relocation, involving the integration of individuals into new social, cultural, and economic environments. In the Czech Republic, where the number of migrants is steadily rising,
Renata Švestková, Lesia Shuranova, Jitka Vacková, Radka Prokešová, Klaudie Němečková   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Adaptation and creativity in cultural context

Revista de Psicología, 2012
Adaptación y creatividad en el contexto cultural La adaptación es la integración entre el individuo y su entorno. El interjuego dinámico entre la persona, la cultura y el entorno es uno de los temas más importantes en el análisis de la creatividad.
Leonora M. Cohen
doaj  

Brief report: cultural adaptations for the PEERS program for Latine families

Frontiers in Education
BackgroundThe UCLA PEERS program has been studied using predominantly White and affluent populations. As autistic teens and their parents are represented across cultures, it is vitally important that interventions are tailored to their needs–whether that
Ann Marie Martin, Ann Marie Martin, Jan Blacher, Elina Veytsman, Elizabeth Baker, Jill Fodstad, Katherine Meltzoff   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Lessons learned by adapting and implementing LUCHA: a deep-structure culturally tailored healthy eating randomized pilot intervention for ethnic-diverse Latinos

Frontiers in Public Health
ObjectivesTo report the adaptation and implementation of LUCHA (Latinos United for a Culturally Healthy Alimentation), a pilot intervention to improve dietary quality and behaviors (primary outcomes) of Latinos in Massachusetts, US, and the lessons ...
Josiemer Mattei, Areli Caballero-González, Ana Maafs-Rodríguez, Ana Maafs-Rodríguez, Amelia Zhang, H. June O’Neill, Cristina Gago, Cristina Gago   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Confusion Assessment Protocol: Italian Cross-Cultural Adaptation and Validation

Brain Sciences
Background: This study validated the Italian version of the Confusion Assessment Protocol (CAP), a tool designed to assess Post-Traumatic Confusional State (PTCS) in patients with severe acquired brain injury (sABI) who are not evaluable with standard ...
Giulia Ferri, Anna Carannante, Manuela Iannetti, Sara Schiattone, Paola Ciurli, Fabiana Mogavero, Valentina Massimi, Marta Aloisi, Rita Formisano, Marco Giustini   +9 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source