Results 131 to 140 of about 4,591,608 (378)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Insights gained from a cultural adaptation of preschool promoting alternative thinking strategies©: the importance of teachers’ cultures as an implementation driver

open access: yesFrontiers in Psychology
IntroductionCultural adaptation of interventions is complex and yet vital to achieving the intended benefits of interventions with new populations. However, little is known regarding deliverers’ perceptions of cultural adaptation and when a cultural ...
Åsa Norman   +4 more
doaj   +1 more source

Socio-Cultural Adaptation of Tuvan Students in Educational Environment of Tomsk [PDF]

open access: diamond, 2020
Olga M. Khomushku   +2 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Adam Smith in Imperial China: Translation and Cultural Adaptation

open access: yesŒconomia, 2012
This paper focuses on the problems of adapting Western economics to the Chinese cultural context using the example of the 1902 translation of Adam Smith’s The Wealth of Nations by Yan Fu.
Olga Borokh
doaj   +1 more source

The Vulnerable State and Technical Fixes: An Analysis of Official Climate Change Discourses in Nepal [PDF]

open access: yes, 2020
I conduct discourse analysis of seven selected official climate change policies and documents of Nepal. In the first part of my analysis, I draw from international climate justice discourses to analyze how policy makers construct Nepal’s position in the ...
Wong, Pearly
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Cultural Diversity, Competencies and Behaviour: Workforce Adaptation of Minorities [PDF]

open access: yes
The increasing mobility of people around the world has resulted in an increasingly culturally diverse workforce, particularly in Canada, where multiculturalism is embraced and government policies are enforced in order to ensure that the Canadian ...
Waheeda Lillevik
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

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