Results 161 to 170 of about 4,289,444 (378)

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

open access: yesFEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash   +6 more
wiley   +1 more source

Cultural Persistence or Experiential Adaptation?

open access: yes, 2017
Studying social trust of immigrants and descendants of immigrants provides leverage for testing whether trust is a persistent cultural trait or, rather, a trait formed and updated by contemporary experiences. The analytical thrust comes from the fact that immigrants were born in (or, in the case of descendants, have ties with) one country, but now ...
Dinesen, Peter Thisted   +1 more
openaire   +3 more sources

PSYCHOMETRIC CHARACTERISTICS OF A SPANISH TRANSLATION OF THE MANCHESTER FOOT PAIN AND DISABILITY INDEX: VALIDATION AND RASCH ANALYSIS [PDF]

open access: yes, 2013
Background: The Manchester Foot Pain and Disability Index (MFPDI) is a self-assessment questionnaire developed in the UK to measure foot pain and disability in the general population1.
Alcacer-Pitarch, Begonya   +6 more
core  

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

open access: yesFEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda   +9 more
wiley   +1 more source

Risk analysis of the Unity 1.5T MR‐Linac adapt‐to‐shape workflow

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background and Purpose The adapt‐to‐shape (ATS) workflow on the Unity MR‐Linac (Elekta AB, Stockholm, Sweden) allows for full replanning including recontouring and reoptimization5. Additional complexity to this workflow is added when the adaptation involves the use of MIM Maestro (MIM Software, Cleveland, OH) software in conjunction with ...
Jiayi Liang   +13 more
wiley   +1 more source

Interpersonal Psychotherapy for Late-life Depression and its Potential Application in China

open access: yesNeuropsychiatric Disease and Treatment, 2020
Hua Xu,1,2 Diana Koszycki2,3 1Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Faculty of Education and Faculty of Medicine, University of Ottawa ...
Xu H, Koszycki D
doaj  

Beyond p‐values: Assessing clinical significance in acupuncture research

open access: yesAdvanced Chinese Medicine, EarlyView.
Abstract In acupuncture randomized controlled trials (RCTs), the proper interpretation of results requires a thorough understanding of key statistical concepts such as p‐value, effect size, and the minimal clinically important difference (MCID). This paper explores the relationships among these metrics and their implications for assessing the clinical ...
Changzhen Gong
wiley   +1 more source

Features sociocultural adaptation armenian youth ekaterinburg [PDF]

open access: yes, 2014
В статье показываются особенности социокультурной адаптации армянской молодежи г. Екатеринбурга. В статье показаны основные проблемы и беспокойства армянской молодежи г. Екатеринбурга относительно вопроса их социокультурной адаптации. В статье предложены
Petrosyan, А. T.   +1 more
core  

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