Results 61 to 70 of about 134,511 (262)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Adaptation and Systems of Cultural Value [PDF]
, 2017 Chapter ...
Kennedy-Karpat, Colleen, Sandberg, E.
openaire +2 more sources
Towards a Wise Despotism: Traces of Thomas Carlyle in the BBC North and South (2004)
Between, 2012 Thomas Carlyle was among the most influential writers in the English language during the 19th century, but is now ostensibly absent from cultural memory. Nevertheless, his ideas may be seen to live on indirectly in the works of the writers he influenced,
Mark Wallace
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Frontiers in PsychologyIntroductionCross-cultural adaptation is a multidimensional process shaped by both contextual resources and individual dispositions, yet it remains unclear whether personality operates uniformly across adaptation domains, particularly in relational host ...
Weihua Tan +3 more
doaj +1 more source
Geosciences, 2018 Changes in rainfall patterns, humidity, and temperature, as well as greater exposure to severe weather events, has led to the need for adapting cultural heritage to climate change. However, there is limited research accomplished to date on the process of
Elena Sesana +3 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Cultural Adaptiveness as a Complex Adaptive System [PDF]
SSRN Electronic Journal, 2015 The objective of this research was to find the structure of adaptiveness in order to use it to organize institutions, whatever their size, from countries to human groups, to generate stable growth. Cultural adaptiveness is the central gravitational force that fosters expansion. It is homologous to institutional expansion processes.
openaire +1 more source