Results 101 to 110 of about 637,329 (305)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Research on Dunhuang Cultural and Creative Product Design

Journal of Creative Arts
In the context of the development of cultural and creative industries, the preservation and transmission of cultural heritage are facing many new opportunities. Using creative design to transform cultural heritage content into cultural and creative products and build a pathway between cultural heritage and contemporary life is a good way to perpetuate ...
Qing Liu, Amer Shakir Zainol, Nurul Huda Mohd Din   +2 more
openaire   +1 more source

Postcards from Somewhere: ‘marginal’ cultural production, creativity and community [PDF]

Australian Geographer, 2010
This paper focuses on a case study of local postcard production in a rural community in Western Australia. Drawing on in-depth interviews with key producers of these postcards, the analysis presented explores perceptions of and contexts for the emergence of this production, in turn examining the notion of ‘creativity’ articulated and privileged by this
openaire   +4 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Retracted: Design Model of Cultural and Creative Products Using User Perception Demand Mining. [PDF]

Comput Intell Neurosci, 2023
Neuroscience CIA.
europepmc   +1 more source

Culture, art, technology, and perception: A creative generation model for museum cultural and creative product design

International Journal of Innovative Research and Scientific Studies
This study is dedicated to an in-depth exploration of the key elements and internal mechanisms of the creative generation of museum cultural and creative products (MCCPs). Given the fragmented state of previous studies and the lack of a unified framework, this study aims to gain a deeper understanding of the creative process of MCCP design.
Daocai Han, Siow-Kian Tan, Booi-Chen Tan
openaire   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Retracted: Image Representational Path of Regional Cultural and Creative Products Based on Genetic Algorithm. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Meningkatkan Citra UKM Melalui Perancangan Ulang Identitas Visual

Humaniora, 2014
The shift of economic trend into creative economy spurs Indonesia as a creative nation supported with cultural diversity, creative human resources and rich of natural resources to actively participate and contribute to the global economy.
Lintang Widyokusumo
doaj   +1 more source