Results 81 to 90 of about 637,329 (305)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Static scheduling method for aircraft flat-tail assembly production based on improved bi-level genetic algorithm

Scientific Reports
Aircraft flat-tail assembly is a complex process that involves multiple assembly processes, multiple parallel frames, and multi-configuration mixed flow assembly, and its assembly processes exhibit extended processing times (typically measured in days ...
Tengda Li, Min Hua, Junliang Wang, Wei Qin   +3 more
doaj   +1 more source

Design of Cultural and Creative Leather Engraving Products based on Minnan Temple Murals Combining Analytic Hierarchy Process and Grounded Theory

Pige Kexue Yu Gongcheng
In order to explore the innovative way of cultural heritage living inheritance, the cultural genes of mural paintings of Minnan Palace Temple are taken as an example, and the design practice of cultural and creative products is carried out by combining ...
Weichang CHEN, Di WU, Shuangyan CAI, Xiaobo LIAN, Linping ZHOU   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Exploring teachers views of creativity: A comparative study [PDF]

, 2016
Previous research on creativity has focussed on what Balkin (1990) called ʻthe three ‘P’s of the creative equation’. Interviews were carried out with 12 music teachers.
Marshall, Nigel, Shibazaki, Kagari
core   +1 more source

Experiential Role of Artefacts in Cooperative Design [PDF]

, 2009
The role of material artefacts in supporting distributed and co-located work practices has been well acknowledged within the HCI and CSCW research. In this paper, we show that in addition to their ecological, coordinative and organizational support ...
Caroll, J.M., Heylen, Dirk K.J., Nijholt, Antinus, van der Veer, Gerrit C., Vyas, Dhaval   +4 more
core   +6 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Purchase intentions for cultural heritage products in E-commerce live streaming: An ABC attitude theory analysis

Heliyon
With the increasing popularity of e-commerce live streaming, understanding purchase intentions for cultural heritage products in this context is crucial, prompting the analysis based on the ABC attitude theory.
Xu Yingqing, Nurul Ain Mohd Hasan, Farhana Muslim Mohd Jalis   +2 more
doaj   +1 more source

The Cultural Economy of Paris [PDF]

The cultural economy is defined in terms of a set of sectors ranging from certain traditional artisanal industries like clothing or jewelry on the one side, to newer media industries like sound recording or television program production on the other.
Allen J. Scott
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source