Results 21 to 30 of about 22,464 (261)
Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases
Advanced Science, EarlyView.There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia +7 more
wiley +1 more source
SAGE Open, 2018 Aims of the current study were to explore teachers’ background, beliefs, attitudes, and sense of self-efficacy, as well as instructional supports and innovative practices in response to cultural and linguistic diversity in classrooms serving Spanish ...
Carla Wood +2 more
doaj +1 more source
Protecting Linguistic and Religious Minorities: Looking for Synergies among Legal Instruments
Religions, 2021 Language and religion are two main cultural markers of collective identities and articulating factors at play in the majority-minority game. However, from a legal and political point of view, language and religion work very differently as factors for ...
Eduardo J. Ruiz Vieytez
doaj +1 more source
Advanced Science, EarlyView.This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan +6 more
wiley +1 more source
Advanced Science, EarlyView.An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu +10 more
wiley +1 more source
Exploring linguistic and cultural diversity at EMI universities in Kuwait
Intercultural Communication EducationThe present study explores cultural and linguistic aspects of diversity in the context of universities with English-medium instruction (EMI) in Arabic-dominant Kuwait.
Marta Tryzna
doaj +1 more source
Advanced Science, EarlyView.As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang +11 more
wiley +1 more source
StackingNet: Collective Inference Across Independent AI Foundation Models
Advanced Science, EarlyView.ABSTRACT Artificial intelligence (AI) built on large foundation models has transformed language understanding, computer vision, and reasoning, yet these systems remain isolated and cannot readily share their capabilities. Coordinating the complementary strengths of independently developed, black‐box foundation models is essential for trustworthy ...
Siyang Li +4 more
wiley +1 more source
Studies in African Languages and CulturesThis study examines an aspect of linguistic globalization known as Englishisation (Kachru 1994; Boussebaa & Brown 2016; Mensah 2021) by adopting the sociolinguistic approach to investigate the creative modifi cations of some Igbo indigenous names with ...
Onyebuchi Nwosu, Chidimma Ugomma Inyima
doaj +1 more source
Lengas, 2015 Morocco is a country where cultural and linguistic diversity is a founding principle registered in the constitution and that all rules set out in any level must respect.
Abdellatif Fdil
doaj +1 more source