Results 61 to 70 of about 86,519 (254)

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang   +16 more
wiley   +1 more source

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

open access: yesAdvanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin   +19 more
wiley   +1 more source

Il museo di antropologia come museo culturale: il caso del MOA di Vancouver

open access: yesAltre Modernità, 2011
This essay will examine anthropology museums as cultural museums from the methodological approach of Cultural Studies. Within this frame, the museum acts as a mode of conservation of material culture thus revealing its immaterial consequences.
Claudia Gualtieri
doaj   +1 more source

Uppsala Latvian Library and Its Donation to Latvia in 1989

open access: yesKnygotyra, 2020
In the USSR-reoccupied Latvia (1944−1990), almost all the Latvian literature, published abroad after World War II, was forbidden to the general public.
Jana Dreimane
doaj   +1 more source

Manifestations of the post-secular emerging within discourses of posthumanism [PDF]

open access: yes, 2013
This paper discusses the concepts of posthuman and post-secular in critical ...
Graham, Elaine L.
core  

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

open access: yesAdvanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du   +6 more
wiley   +1 more source

Embodied memory and curatorship in children’s digital video production [PDF]

open access: yes, 2010
Digital video production in schools is often theorised, researched and written about in two ways: either as a part of media studies practice or as a technological innovation, bringing new, “creative”, digital tools into the curriculum.
Potter, John
core   +2 more sources

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

open access: yesAdvanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira   +18 more
wiley   +1 more source

Zelige Door on Golborne Road

open access: yesDigital Humanities in the Nordic and Baltic Countries Publications, 2018
In this paper I discuss the multisensory digital interface and art installation Zelige Door on Golborne Road as part of the wider research project ‘Mapping Memory Routes: Eliciting Culturally Diverse Collective Memories for Digital Archives’.
Alda Terracciano
doaj   +1 more source

'Chineseness': The work of Lo Yuen-yi in memory of the women of Nushu [PDF]

open access: yes, 2016
One of the difficulties facing art historians and curators when approaching recently produced artworks is how to interpret such works within the dominant narrative of art history and its traditional axis of historical time and geographical place.
Foster, Nicola
core   +1 more source

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