The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda+9 more
wiley +1 more source
Intercultural Design for Use – Extending Usage-Centered Design by Cultural Aspects
Helmut Windl, Rüdiger Heimgärtner
openalex +1 more source
Spatial evolution characteristics and influencing factors of sports brand resources in Chinese urban agglomerations. [PDF]
Zhong X, Wang J, Zhong Z.
europepmc +1 more source
Risk analysis of the Unity 1.5T MR‐Linac adapt‐to‐shape workflow
Abstract Background and Purpose The adapt‐to‐shape (ATS) workflow on the Unity MR‐Linac (Elekta AB, Stockholm, Sweden) allows for full replanning including recontouring and reoptimization5. Additional complexity to this workflow is added when the adaptation involves the use of MIM Maestro (MIM Software, Cleveland, OH) software in conjunction with ...
Jiayi Liang+13 more
wiley +1 more source
Mental health and quality of life in dialysis and transplant patients in Vietnam: a call for integrated care models. [PDF]
Nguyen AM, Vo LH.
europepmc +1 more source
Beyond p‐values: Assessing clinical significance in acupuncture research
Abstract In acupuncture randomized controlled trials (RCTs), the proper interpretation of results requires a thorough understanding of key statistical concepts such as p‐value, effect size, and the minimal clinically important difference (MCID). This paper explores the relationships among these metrics and their implications for assessing the clinical ...
Changzhen Gong
wiley +1 more source
Family life under strain: the impact of forced migration on refugee parenting in reception centers. [PDF]
Drummond Johansen J+2 more
europepmc +1 more source
Mitochondrial DNA disorders in neuromuscular diseases in diverse populations
Abstract Neuromuscular features are common in mitochondrial DNA (mtDNA) disorders. The genetic architecture of mtDNA disorders in diverse populations is poorly understood. We analysed mtDNA variants from whole‐exome sequencing data in neuromuscular patients from South Africa, Brazil, India, Turkey and Zambia. In 998 individuals, there were two definite
Fei Gao+34 more
wiley +1 more source
Assessment of Dementia in Minority Ethnic Groups in Europe: A 14-Year Follow-Up Survey. [PDF]
Nielsen TR+7 more
europepmc +1 more source