Results 51 to 60 of about 2,819,686 (314)

S'Esclop. Quadern cultural 2003, no. 11 [PDF]

, 2003
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Esclop Associació Cultural
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

S'Esclop. Quadern cultural 2010, no. 52 [PDF]

, 2010
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Esclop Associació Cultural
core  

Lithuanian National Cultural Periodical Publishing in 1997–2018: Processes of Change and Adaptation

Knygotyra
Cultural periodicals are an important part of a nation’s cultural identity, and their mission is cultural reflection. This article analyzes the main changes in publishing which took place in the field of Lithuanian cultural periodicals during the period
Asta Urbanavičiūtė-Globienė
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

S'Esclop. Quadern cultural 2002, no. 2 [PDF]

, 2002
not ...
Esclop Associació Cultural
core  

Un second souffle. La danse des búzios au prisme de sa « réaffirmation » culturelle par les Pankararu, Pernambouc, Brésil

Journal de la Société des Américanistes
This article proposes to reflect on the contemporary circulation of indigenous aerophones—known as búzios—and the cultural and political practices associated with them. Based on the case of the dance of the búzios of the Pankararu Indians of the State of
Cyril Menta
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

S'Esclop. Quadern cultural 2007, no. 35 [PDF]

, 2007
not ...
Esclop Associació Cultural
core  

I memi come parodia del discorso politico italiano durante la pandemia di Covid-19 (2020-2021).

EtnoAntropologia, 2022
This essay presents my interpretation of the production and circulation of memes as a parody of the Italian political and media discourse during the pandemic. The term meme and the viral circulation of visual and audiovisual messages can, in my opinion,
Franco Lai
doaj   +2 more sources