Results 91 to 100 of about 2,859,539 (300)

Missiological Education by Extension: A Case Study of the Course, “Foundations of the World Christian Movement” [PDF]

open access: yes, 2010
This article is a case study of a simple online course created jointly by a mission agency and small university. It demonstrates how open source course management technology has been used to create a true sense of community among students from a variety ...
Smith, Rick, Snodderly, Mary E.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Contributions of Cultural Journalism in Algeria and its Role in Shaping Intellectual and Cultural Identity

open access: yesمجلة العلوم و آفاق المعارف
Journalism is considered a fundamental tool in disseminating culture, shaping intellectual eliteand reinforcing them through the presentation of news, information, and ideas in the fields of literature, arts, and sciences.
Halima Aiche
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Multimodality of cultural content in ELT materials for young learners.

open access: yesTheory and Practice of Second Language Acquisition, 2017
Cultural content is incorporated into EL materials to enrich linguistic content. The paper focuses on English materials as cultural artefacts analysed in terms of multimodality.
Maria Dorota Stec
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Exploration of numeracy in digital cultural content

open access: yesEducational Challenges
The PISA results of 2022 awarded Indonesian students poor scores in literacy and numeracy. Previous studies have suggested that numeracy skills can be improved by applying game-based learning to ethnomathematics.
Ni Luh Sakinah Nuraini   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Interdiscursive Readings in Cultural Consumer Research [PDF]

open access: yes, 2018
The cultural consumption research landscape of the 21st century is marked by an increasing cross-disciplinary fermentation. At the same time, cultural theory and analysis have been marked by successive ‘inter-’ turns, most notably with regard to the Big ...
Rossolatos, George
core  

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