Results 111 to 120 of about 1,202,282 (291)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
LA DIMENSIÓN CULTURAL DEL TEXTO DESDE LA PERSPECTIVA TRADUCTOLÓGICA [PDF]
Studii de gramatică contrastivă, 2017 : El artículo se propone investigar el aporte de perspectivas traductológicas en el estudio de la dimensión cultural del texto. Se hace hincapié en la necesidad de destacar factores meramente lingüísticos y extralingüísticos que conforman la dimensión ...
Hasmik Baghdasaryan
doaj
Making sense of institutional change in China: The cultural dimension of economic growth and modernization [PDF]
Building on a new model of institutions proposed by Aoki and the systemic approach to economic civilizations outlined by Kuran, this paper attempts an analysis of the cultural foundations of recent Chinese economic development.
Herrmann-Pillath, Carsten
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
La dimensión cultural en los estudios de innovación
Revista Atlántida, 2013 En la literatura especializada sobre innovación existe un interés creciente por investigar el papel de la cultura en la dinámica económica global. Más concretamente, en las actividades de innovación de las empresas y en los resultados económicos de los ...
Madelon van Oostrom, Dra.
doaj +2 more sources
Silk roads of the twenty-first century:The cultural dimension [PDF]
, 2017 Dellios, Rosita
core +1 more source
The Social Wellbeing of New York City's Neighborhoods: The Contribution of Culture and the Arts [PDF]
, 2017 This report presents the conceptual framework, data and methodology, and findings of a two-year study of culture and social wellbeing in New York City by SIAP with Reinvestment Fund.
Mark J. Stern, Susan C. Seifert
core
Dataset on The Cultural Dimension of Urban Society Food Consumption in Indonesia. [PDF]
Data Brief, 2020 Seda FS, Setyawati L, Tirta T, Nobel K.
europepmc +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source