Results 51 to 60 of about 1,202,282 (291)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

A theory of the city as object: or, how spatial laws mediate the social construction of urban space [PDF]

, 2001
A series of recent papers (Hillier et al 1993, Hillier 1996b, Hillier 2000) have outlined a generic process by which spatial configurations, through their effect on movement, first shape, and then are shaped by, land use patterns and densities. The aim
Hillier, B.
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

THE CULTURAL DIMENSION [PDF]

Surfaces, 2019
A study of the relationship between culture and technology in the writings of Benjamin and Gramsci, with special reference to its impact on the notion of the nation state.
openaire   +1 more source

Cultural Orientations of sport managers [PDF]

, 2006
Various interpretations of sport management are cultural constructs underpinned by core assumptions and values held by members of professional communities. Sport managers world wide share common problems, but differ in how they resolve them.
Adler N., Azzopardi K., Berg B. L., Bloom H., Blouet B., Bobev S., Brannen M., Bryman A., Charmaz K., Chelladurai P., Chelladurai P., Chen M., Colyer S., Costa C., Darlington G., Davis K., Dayan D., Denscombe M., DeSensi J., DeSensi J., DeSensi J. T., DeSensi J. T., Dimitra Papadimitriou, Doherty A., Hall E. T., Hall E. T., Hampden-Turner C., Hampden-Turner C., Hickson D., Hickson D., Hofstede G., Hofstede G., Hofstede G., Hofstede G., Holden N., Inkeles A., Jackson R., Jackson T., Kikulis L., Kluckhohn F., Lessem R., Lewis J., Lewis R. D., Lewis R. D., Martin J., Masteralexis L., Minter R., Nicholson J., Oakley B., Palmer A., Parkhouse B., Rokeach M., Rosa López De D'Amico, Sands R., Schein E., Schneider S., Seagrave S., Slack T., Smith P., Soucie D., Taylor T., Taylor T., Taylor T., Torkildsen G., Triandis H.C., Trompenaars F., Trompenaars F., Trompenaars F., Vassil Girginov, Weese W., Westerbeek H., Willett C., Zetterholm S., Zolotov M.   +73 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Cultural Dimension of Revolution: New Images of Man

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2017
The turning points of the history are characterized by people’s active participation in one of the most natural for the man social activity – the creation of new self-images.
Maksim M. Zagorulko, Irina A. Petrova, Irina K. Cheremushnikova   +2 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Cultural Cooperation as a Dimension of Development Cooperation

Nordic Journal of African Studies, 1992
Cultural Cooperation as a Dimension of Development ...
Kari Karanko
doaj   +1 more source

The historical dimension as a guide-tool identification and reading wine landscape character of Mendoza, Argentina [PDF]

, 2016
The wine landscape of the province of Mendoza is characterized by an integrating heterogeneity and active, own agricultural production activity dynamism. This is considered as a cultural heritage and a provincial collective redress.
Manzini Marchesi, Lorena Verónica
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