Results 61 to 70 of about 1,202,282 (291)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Cultural Barriers and Agricultural Trade in the Western Hemisphere [PDF]

This study analyzes the impacts of cultural distance on bilateral trade flows in the Western Hemisphere using a Fixed Effects Vector Decomposition (FEVD). Four cultural dimensions of Hofstede are used to capture cultural distance.
Rosson, C. Parr, III, Susanto, Dwi
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Beyond Hofstede Dimension Model: A New Cultural Dimension of Context Culture

International Journal of Languages, Literature and Linguistics, 2023
With significant political and economic changes over the decades, the limitations of Hofstede's cultural difference dimension model have been heated debated. The purpose of this research is to explore the levels of context culture among people in China of different ages and genders and whether context culture should be considered as part of the ...
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Poder cultural y social: dimensión viral de la globalización

Ehquidad, 2020
El poder y todos los procesos de control del mismo son parte de los gérmenes culturales nocivos de la dimensión negativa de la globalización cultural, cuyo origen puede estar asociado en parte con el egoísmo biológico, que nos lleva a la relación ...
Javier García Bresó
doaj   +1 more source

The fourth dimension in landscape analysis: changing of heritage and ecological values in the Évora cultural landscapes. [PDF]

, 2011
Time is one of the most important driving forces in Landscape Ecology. Time along with geosystem, biosystem and socialsystem determines landscape heterogeneity which reveals itself in different patterns and functions.
Batista, Teresa, Mascarenhas, José Manuel de, Mendes, Paula   +2 more
core  

A revaluation of the cultural dimension of disability policy in the European Union: The impact of digitization and web accessibility [PDF]

, 2014
Reflecting the commitments undertaken by the EU through the conclusion of the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD), the European Disability Strategy 2010–2020 not only gives a prominent position to accessibility ...
Anderson, Aylett, Barnes, Barton, Beiter, Blanck, Blanck, Brown, Burchardt, Cook, Cornu, Cortese, Degener, Disability Studies Quarterly, Donders, Easton, Easton, Easton, Easton, Ferri, Gompel, Harnacke, Harpur, Hosking, Kayess, Koch, Kongolo, Kuzma, Laaksonen, Lewinski, Mabbett, Mercer, Michailakis, Moreno, Muñoz Machado, Oliver, Pineschi, Quinn, Quinn, Rekas, Ritchie, Sandler, Seatzu, Smith, Smith, Stamatopoulou, Stein, Summer, Toolkit, Traustadottir, UN, UN, UN, UN, UN, UNESCO, Waddington, Waddington, WIPO, Zagato   +59 more
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source