Results 61 to 70 of about 1,207,433 (312)

A theory of the city as object: or, how spatial laws mediate the social construction of urban space [PDF]

, 2001
A series of recent papers (Hillier et al 1993, Hillier 1996b, Hillier 2000) have outlined a generic process by which spatial configurations, through their effect on movement, first shape, and then are shaped by, land use patterns and densities. The aim
Hillier, B.
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cultural Barriers and Agricultural Trade in the Western Hemisphere [PDF]

This study analyzes the impacts of cultural distance on bilateral trade flows in the Western Hemisphere using a Fixed Effects Vector Decomposition (FEVD). Four cultural dimensions of Hofstede are used to capture cultural distance.
Rosson, C. Parr, III, Susanto, Dwi
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Beyond Hofstede Dimension Model: A New Cultural Dimension of Context Culture

International Journal of Languages, Literature and Linguistics, 2023
With significant political and economic changes over the decades, the limitations of Hofstede's cultural difference dimension model have been heated debated. The purpose of this research is to explore the levels of context culture among people in China of different ages and genders and whether context culture should be considered as part of the ...
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Poder cultural y social: dimensión viral de la globalización

Ehquidad, 2020
El poder y todos los procesos de control del mismo son parte de los gérmenes culturales nocivos de la dimensión negativa de la globalización cultural, cuyo origen puede estar asociado en parte con el egoísmo biológico, que nos lleva a la relación ...
Javier García Bresó
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Persuasive argumentation as a cultural practice [PDF]

, 2014
In this article author traces relation between argumentation and cultural practice. The first part focuses on definition of argumentation in informal logic tradition.
GAŁKOWSKI, Paweł
core   +1 more source