Results 71 to 80 of about 1,207,433 (312)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
The fourth dimension in landscape analysis: changing of heritage and ecological values in the Évora cultural landscapes. [PDF]
, 2011 Time is one of the most important driving forces in Landscape Ecology. Time along with geosystem, biosystem and socialsystem determines landscape heterogeneity which reveals itself in different patterns and functions.
Batista, Teresa +2 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
THE APPLICABILITY OF WIDELY EMPLOYED FRAMEWORKS IN CROSS-CULTURAL MANAGEMENT RESEARCH [PDF]
This article aims to analyze and assess the applicability of widely employed frameworks in cross-cultural management research. First, some criteria are conceptualized and then, eight cultural frameworks are examined and their relevance with respect to ...
Daniel Sauers, Hamid Yeganeh, Zhan Su
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
An Analysis of Diversity Management Through Cultural Dimensions
Theory, Methodology, Practice, 2010 Dealing with social pressure for equal treatment and opportunities has been one of the most important business issues in modern times. Countries are dealing with this issue in different ways, with different approaches and levels of maturity according to
Ana Sperancin
doaj
Cartography of corruption in Colombia: an approach to the social, cultural and economic dimensions
Cogent Social SciencesThe study examines how corruption affects various dimensions in Colombia, specifically social, cultural and economic dynamics. It underscores the importance of analyzing the interrelations between corruption and democracy, ethics, human behavior, tourism,
Ibis Danilo Yanguas-Botero +2 more
doaj +1 more source
The Normative and Cultural Dimension of Work: Technological Unemployment as a Cultural Threat to a Meaningful Life. [PDF]
J Bus Ethics, 2023 Mejia S.
europepmc +1 more source
The effect of culture on online learning [PDF]
, 2010 The author is conducting survey research to identify possible effects of\ud culture on online learning success. The research will consider the cultural\ud dimension of uncertainty avoidance identified by Hofstede (2001). The research\ud participants will
Kinasevych, Orest
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source