Results 131 to 140 of about 168,693 (266)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The Role of National Cultural Dimensions in Pandemic Outcomes: A Cross-Sectional Study Across 90 Countries During the COVID-19 Pandemic. [PDF]

Healthc Technol Lett
Chou HH, Sheu RS, Chiang CI.
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Integrating cultural dimensions in sperm whale (<i>Physeter macrocephalus</i>) conservation: threats, challenges and solutions. [PDF]

Philos Trans R Soc Lond B Biol Sci
Eguiguren A, Avila I, Mesnick S, Cantor M, Hersh T, Pérez-Puig H, Rosero P, Rendell L, Whitehead H, Rojas C, Alava JJ.   +10 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

The impact of gender, psychology, and cultural dimensions on leadership development in distance education. [PDF]

Sci Rep
Abdallah AK.
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Social, psychological, and cultural dimensions of cardiovascular health among Hispanic/Latino adults: A narrative review of findings from the Hispanic Community Health Study/Study of Latinos. [PDF]

Health Psychol
Gallo LC, Rosas CE, McCurley JL, Hernandez Mozo E, Penedo FJ, Roesch SC, Llabre MM, Perreira KM, Sotres-Alvarez D, Talavera GA, Wassertheil-Smoller S, Pirzada A, Daviglus ML, Cordero C, Kaplan RC, Rodriquez EJ, Pérez-Stable EJ, Kunz J, Isasi CR.   +18 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Variations in obsessive compulsive disorder symptomatology across cultural dimensions. [PDF]

Front Psychiatry
Hassan W, El Hayek S, de Filippis R, Eid M, Hassan S, Shalbafan M.   +5 more
europepmc   +1 more source