Results 91 to 100 of about 6,500,234 (345)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Explorer la distance culturelle entre les acquis de première socialisation des élèves inuit et le programme de scolarisation formel au Nunavik

open access: yesIdeAs
Students in Nunavik are currently educated under a trilingual and bicultural education system. In this context, their educational trajectory is marked by breaking points that affect their perseverance and academic success.
Glorya Pellerin   +4 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

A Conceptual Model of Cultural Distance, MNC Subsidiary Roles, and Knowledge Transfer in China-based Subsidiaries

open access: yesOrganizations and Markets in Emerging Economies, 2011
This conceptual paper seeks to review the literature on international strategic management, examine the trilateral interactive relations among national culture, subsidiary strategic context and knowledge transfer between China-based subsidiaries and ...
Cindy Qin, Prem Ramburuth, Yue Wang
doaj   +1 more source

Why we should stop using the Kogut and Singh Index [PDF]

open access: yes, 2019
The Kogut and Singh (J Int Bus Stud 19(3):411–432, 1988) index is the most widely used construct to measure cultural distance in international business and management research.
Konara, Palitha, Mohr, Alex
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The Many Faces of Distance – A Typology of Distance in Management

open access: yesEuropean Journal of Management Issues, 2021
Purpose: Based on the various streams of distance literature in management, a framework is provided to make discourses on distance clear. Design / Method / Approach: After a review of the most relevant distance concepts, a typology with five categories ...
Moritz Martin Botts
doaj  

The effect of cultural background on metaphor interpretation [PDF]

open access: yes, 2003
This article describes a study that investigated the ways in which Bangladeshi students interpreted metaphors used by their lecturers during a short course at a British university.
Bertocci   +4 more
core   +1 more source

Psychological Distance and Culture

open access: yes, 2019
This chapter introduces psychological distance into cultural studies as an alternative way of conceptualizing individual differences. Unlike most cross-cultural frameworks that are at the group level, psychological distance provides an individual level conceptualization of distance.
openaire   +1 more source

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