Results 111 to 120 of about 6,500,234 (345)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Kulturvermittlung im Spannungsfeld von Texttreue und äußeren Kontrollfaktoren

Interkulturelles Forum der deutsch-chinesischen Kommunikation
Auf dem globalen Buchmarkt ist die deutschsprachige Gegenwartsliteratur lediglich ein Nischenthema. Umso erfreulicher ist es, dass die Romane von Jenny Erpenbeck, die mittlerweile als Deutschlands international renommierteste Schriftstellerin gilt, große
Hui Leng
doaj   +1 more source

The Hetu'u Global Network: Measuring the Distance to the Sun Using the June 5th/6th Transit of Venus

, 2012
In the spirit of historic astronomical endeavors, we invited school groups across the globe to collaborate in a solar distance measurement using the rare June 5/6th transit of Venus. In total, we recruited 19 school groups spread over 6 continents and 10
Faherty, Jacqueline K., Miller, Scott T., Rodriguez, David R.   +2 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Impact of Cultural Distance and Perceived Discrimination on the Behavioral Intentions of International Students: A Case Study at Shahid Sadoughi University of Medical Sciences, Yazd [PDF]

Pizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī
Introduction: “Cultural distance” and “perceived discrimination” are two key factors that influence individuals’ experiences in cross-cultural environments, which can affect their satisfaction, academic performance, and even their intention to stay in ...
Mehdi Raadabadi, Hosein Amery, Ali Dehghan Mirkabad   +2 more
doaj  

Cultural Proximity and Bilateral Trade in the European Union [PDF]

, 2011
Since its origins, the European Union has been focused on removing the barriers to the full integration of its members’ economies. But while formal institutions have adapted, have informal social norms also changed?
Cyrus, Teresa L.
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Cultural distance and the image of a migrant among the Russian population of Tatarstan: “foreign”, “different”, “tolerable” [PDF]

Вестник археологии, антропологии и этнографии
The article considers the features of the perception of migrants by the Russian population of the Republic of Tatarstan, reflecting the degree of the intergroup social distance.
Kozlov V.E.
doaj   +1 more source

How academic performance influences social integration: The moderation effect of cultural distance among Chinese cross-borderers. [PDF]

Brain Behav, 2022
Jieyi H, Kiu CC, Baojian X.
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source