Results 261 to 270 of about 1,330,064 (298)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Cultural evolution in the science of culture and cultural evolution

Physics of Life Reviews, 2023
My critical review [1] elicited a welcome diversity of perspectives across the 12 commentaries now published [2-13]. In total 28 co-authors were inspired to contribute. In addition to engaging with the critical perspectives of my review, several of the commentaries take the debates and discussions into insightful and potentially important supplementary
openaire   +2 more sources

The Pace of Cultural Evolution

open access: yesPLoS ONE, 2012
Today, humans inhabit most of the world's terrestrial habitats. This observation has been explained by the fact that we possess a secondary inheritance mechanism, culture, in addition to a genetic system. Because it is assumed that cultural evolution occurs faster than biological evolution, humans can adapt to new ecosystems more rapidly than other ...
Charles Perreault
exaly   +5 more sources

The evolution of cultural evolution

Evolutionary Anthropology: Issues, News, and Reviews, 2003
AbstractHumans are unique in their range of environments and in the nature and diversity of their behavioral adaptations. While a variety of local genetic adaptations exist within our species, it seems certain that the same basic genetic endowment produces arctic foraging, tropical horticulture, and desert pastoralism, a constellation that represents a
Henrich, J.   +1 more
openaire   +3 more sources

Cultural evolution: Conserved patterns of melodic evolution across musical cultures

Current Biology, 2022
A new study finds that melodies evolve in similar ways, reminiscent of genetic evolution, across cultures. Patterns of change in music and other aesthetic domains may be the key to understanding how culture evolves when unfettered by physical or ecological constraints.
Hoeschele, Marisa, Fitch, W. Tecumseh
openaire   +2 more sources

Ethics, evolution and culture

Theory in Biosciences, 2008
Recent work in the fields of evolutionary ethics and moral psychology appears to be converging on a single empirically- and evolutionary-based science of morality or ethics. To date, however, these fields have failed to provide an adequate conceptualisation of how culture affects the content and distribution of moral norms.
Alex Mesoudi, Peter Danielson
openaire   +2 more sources

Childhood and cultural evolution

Journal of Analytical Psychology, 2022
AbstractAlready in 1912, Sabina Spielrein addressed the transforming and antagonistic movements of life that appear from conception in her work ‘Destruction as the cause of coming into being’. Her writings form a bridge between Freud and Jung, as they establish the relationship between biological experiences and archetypes.
openaire   +2 more sources

Evolution, Culture, and Psychopathology

The Journal of General Psychology, 1968
(1968). Evolution, Culture, and Psychopathology. The Journal of General Psychology: Vol. 78, No. 2, pp. 151-164.
M, Hammer, J, Zubin
openaire   +2 more sources

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