Results 131 to 140 of about 569,923 (312)

Pacific History, Museums and Cultural Centres; A Guide for History teachers [PDF]

open access: yes, 2003
This booklet was produced to promote educational use of Museums and cultural centres and to support history teachers in the Pacific Islands. It was delivered free of chrage to schools, institutions in the region.
Quanchi, Max
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Insomnia: a cultural history [PDF]

open access: yesThe Lancet, 2018
Whitehead, Kimberley, Beaumont, Matthew
openaire   +4 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Educational and Cultural Profile, Liberia, undated [PDF]

open access: yes
This material is part of the Bureau of Educational and Cultural Affairs Historical Collection, Group III. Fulbright Program, 1947-1983, Series 1. Fulbright Program General Files, 1940-1979, Subseries 1, General and Historical Files, 1940-1979.

core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Educational and Cultural Profile, Turkey, undated [PDF]

open access: yes
This material is part of the Bureau of Educational and Cultural Affairs Historical Collection, Group III. Fulbright Program, 1947-1983, Series 1. Fulbright Program General Files, 1940-1979, Subseries 1, General and Historical Files, 1940-1979.

core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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