Results 161 to 170 of about 568,894 (312)

Arctos: Community-driven innovations for managing natural and cultural history collections. [PDF]

PLoS One
Cicero C, Koo MS, Braker E, Abbott J, Bloom D, Campbell M, Cook JA, Demboski JR, Doll AC, Frederick LM, Linn AJ, Mayfield-Meyer TJ, McDonald DL, Nachman MW, Olson LE, Roberts D, Sikes DS, Witt CC, Wommack EA.   +18 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Migracions, canvi cultural i ciutadania a Catalunya (1920-1980)

Cercles: revista d'Història Cultural, 2016
Intellectual and Cultural History Group GEHCI
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Educational and Cultural Profile, India, undated

This material is part of the Bureau of Educational and Cultural Affairs Historical Collection, Group III. Fulbright Program, 1947-1983, Series 1. Fulbright Program General Files, 1940-1979, Subseries 1, General and Historical Files, 1940-1979.

core  

History of International Educational Exchange Written in 1960s

, 1959
This material is part of the Bureau of Educational and Cultural Affairs Historical Collection, Group III. Fulbright Program, 1947-1983, Series 1. Fulbright Program General Files, 1940-1979, Subseries 1, General and Historical Files, 1940-1979.

core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Educational and Cultural Profile, Ecuador, undated

This material is part of the Bureau of Educational and Cultural Affairs Historical Collection, Group III. Fulbright Program, 1947-1983, Series 1. Fulbright Program General Files, 1940-1979, Subseries 1, General and Historical Files, 1940-1979.

core  

History of International Educational Exchange Written in 1970s

, 1972
This material is part of the Bureau of Educational and Cultural Affairs Historical Collection, Group III. Fulbright Program, 1947-1983, Series 1. Fulbright Program General Files, 1940-1979, Subseries 1, General and Historical Files, 1940-1979.

core