Results 41 to 50 of about 71,463 (307)

Mapping the public sector diaspora: towards a model of inter-sectoral cultural hybridity using evidence from the English healthcare reforms [PDF]

, 2015
Public service reforms increasingly blur the boundaries between public and private sectors, involving hybrid modes of service organization. With growing numbers of public services being transferred to private or mutual ownership, the article interprets ...
Ackermann, Alcock, Bate, Berg, Berry, Bhabha, Billis, Boyne, Brubaker, Clifford, Cohen, Cooke, Department of Health, Department of Health, Department of Health, Esman, Ferlie, Fortier, Gabbay, Hall, Hebdige, Hebson, Hodge, Jones, Kalra, Lo, Lobell, Marchington, McDonough, Noordegraaf, Oliver, Ovretveit, Perry, Perry, Pieterse, Pieterse, Pratchett, Pratt, Rondeaux, Safran, Smith, Stackman, Stephenson, Strauss, Strauss, Stross, Turner, Waring, Waring, Waring, Weisberger, Yao, Young   +52 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

La conquista dell’ibridità nella fiction di Meera Syal

Linguae &: Rivista di Lingue e Culture Moderne, 2014
The aim of this essay is to explore Meera Syal’s novels – Anita and Me and Life isn’t all ha ha hee hee – and to suggest that they show and sponsor a level of hybridity that I call ‘ibridità conclamata’ (full-blown hybridity), a condition in which the ...
Sergio Guerra
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Exploring Cultural Hybridity Branded by Convergence and Syncretism in the Characteristic Features of the Pentecostal Charismatic Churches in Zimbabwe: Implications for Spiritual and Material Well-Being

Religions
When applied to Pentecostalism in Zimbabwe, the concept of cultural hybridity provides a framework for understanding how global religious movements can adapt to and incorporate local cultural elements.
Francis Marimbe
doaj   +1 more source

Navigating the bio-politics of childhood [PDF]

, 2011
Childhood research has long shared a bio-political terrain with state agencies in which children figure primarily as ‘human futures’. In the 20th century bio-social dualism helped to make that terrain navigable by researchers, but, as life processes ...
Lee, Nick, Motzkau, J.
core   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Liminal Margins and the Appropriation of the Inherited Codes and Imposed Patterns in Abdulrazak Gurnah’s The Last Gift

Nalans
The study explores the immigrant’s identity crisis in Abdulrazak Gurnah’s The Last Gift from the lens of hybridity and liminality. It analyses how the host society determines identity formation and the tension they experience between their cultural ...
Fikret Güven
doaj   +1 more source