Results 41 to 50 of about 4,409 (247)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
So What Do Polar Bears Think about Us?
Humanimalia, 2017 Michael Engelhard. Ice Bear: The Cultural History of an Arctic Icon. Seattle: University of Washington Press, 2017. xiii, 288 pp. $29.95 (pb)
Margery Fee
doaj +1 more source
The Iconography of John Ford's Westerns
Linguaculture, 2020 This paper follows the way in which the filmography of the movie director John Ford presents cultural icons. We discuss the symbolism of these images and their cultural significance in the larger context of the West as a cultural area and American ...
Irina Chirica
doaj +1 more source
Mokranjac, culture, and icons [PDF]
New Sound, 2014 The 100th anniversary of Mokranjac's death provides an opportunity to consider his work from the perspective of a "cultural icon", in so far as his music and the composer himself have gained such an iconic status in the context of Serbian music. His output in ethnography and composition alike has not only itself become an "icon", but also paved the way
openaire +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
, 2021 Examining the numerous meanings and symbolic incarnations of Vladimir Ilich Lenin after his death in 1924, this chapter examines how icons may be used to articulate political positions, and how in processes of contesting and re-negotiating history, icons function in relation to collective remembrance.
openaire +3 more sources