Results 41 to 50 of about 150,645 (307)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Effects of Icon Characteristics and Metaphors on the Recognition of Icons by Students With Different Knowledge Structures

IEEE Access
Icons are widely used to communicate information in graphical user interfaces, and it is essential for designers to understand how users recognize and interpret them.
Zhao Xin, Ma Jin, Wu Guo Chao, Zhang Qing Qing   +3 more
doaj   +1 more source

Rhythm and Metaphor in the Art of the Icon

Слово.ру: балтийский акцент, 2017
Using art history interpretation methods and the methods of historical cultural studies, the author demonstrates the role of rhythm and metaphor as the most expressive artistic means of icon painting. The interaction of rhythm and metaphor is an integral
Gubareva O. V.
doaj   +1 more source

Repetition, Recognition, Remediation Or Benito Mussolini after Benito Mussolini

Ocula, 2020
The main goal of this contribution is to investigate the way in which a figure of memory, the image of a person linked to an event of the past, symbolically travels in a specific culture.
Mario Panico
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

L'icona invisibile. Big Brother da icona finzionale a icona culturale

Ocula, 2020
In George Orwell's 1984, Big Brother is the inscrutable leader of Oceania. Thanks to his media pervasiveness, his image assumes, an iconic value, expression par excellence of control and power.
Paolo Bertetti
doaj   +1 more source

Lessons from Brecht: a Brechtian approach to drama, texts and education [PDF]

, 1999
In this piece the authors seek to re-read Brecht in terms of his contribution to drama education and pedagogic thought, rather than viewing him in conventional terms as a cultural icon and ‘great practitioner’ of theatre.
Franks, Anton, Jones, Ken
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

So What Do Polar Bears Think about Us?

Humanimalia, 2017
Michael Engelhard. Ice Bear: The Cultural History of an Arctic Icon. Seattle: University of Washington Press, 2017. xiii, 288 pp. $29.95 (pb)
Margery Fee
doaj   +1 more source

David superstar. Guan Xiao e le icone nell'arte

Ocula, 2020
It is enough to look around to be "touched" by an immense quantity of reproductions of works of art of every age and style. Not any image, but certain works that have become part of the collective imagination until they become true icons.
Lucia Corrain, Ottavia Mosca
doaj   +1 more source