Results 111 to 120 of about 1,986,126 (300)

Towards the estimation of the economic value of the outputs of Scottish higher education institutions : Next Steps Summary Report [PDF]

open access: yes, 2008
This paper represents a summary of the 'Next Steps Project' which piloted the practical application of a new methodological approach applying welfare economic principles to estimate the value of non-market outputs of higher education institutions.
Brooks, Richard   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Valuing Australian cultural institutions: developing a cultural worldview scale

open access: yes, 2006
This paper explores the relationship between cultural attitudes and estimates of the economic value of cultural institutions. The relationship is tested with preliminary findings from an empirical study of the economic value of two national cultural ...
Bennett, Jeff, Choi, Andy, Papandrea, F
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

A Guide to Distributed Digital Preservation [PDF]

open access: yes, 2010
This volume is devoted to the broad topic of distributed digital preservation, a still-emerging field of practice for the cultural memory arena. Replication and distribution hold out the promise of indefinite preservation of materials without degradation,
Schultz, Matt, Skinner, Katherine
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Exploring relations between community gardens and cultural institutions in terms of diverse governance models: A case study of Warsaw and Poznań, Poland

open access: yesPrzegląd Geograficzny
The ongoing academic debate shows that urban community gardening has diverse governance models with differing roles for governmental organizations, NGOs and local communities.
Barbara Maćkiewicz, Paulina Jeziorek
doaj   +1 more source

Culture, Institutions and the Wealth of Nations [PDF]

open access: yes
We construct an endogenous growth model that includes a cultural variable along the dimension of individualism-collectivism. The model predicts that more individualism leads to more innovation because of the social rewards associated with innovation in ...
Gorodnichenko, Yuriy, Roland, Gerald
core  

ROLE OF SUPPORT COMMUNITY AND NEDERLANDSH INDISCHE KUNSTRING AS COMPONENTS OR THE MOOI INDIE FINE ARTS [PDF]

open access: yes, 2010
This research is focused on the importance of role played by the supporting society and art institutions,especially Nederlandsche Indeische Kunstring to encourage development of Mooi Indie painting.
M. Agus, Burhan
core  

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