Results 121 to 130 of about 6,684,309 (261)
Buddhism’s Knotted Thread (結縷法): Indian Origins and Chinese Adaptations
ReligionsThe Buddhist “Knotted Thread” originates from the ancient Indian practice of venerating sacred threads. In Indian culture, sacred threads symbolize identity and status and possess functions such as exorcism, healing, disaster prevention, blessing ...
Gang Yang
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Cultural Impact Indexes: background, methodology and results
, 2017 The result recorded in this document is summarized as a methodological finding that can be used to define a battery of cultural effect and impact indicators and to construct cultural impact indexes.
Banco de la República (Bogotá). Subgerencia Cultural; Barona Tovar, Fernando; Cuéllar Caicedo, Edwin Javier
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Institute on Community Integration Annual Report: 2000-01
, 2001 The annual report summarizing the work and community impact of the Institute on Community Integration, a federally–designated University Affiliated Program on Developmental Disabilities working to improve community services and social supports for ...
Institute on Community Integration
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Culture formation and endogenous cultural distance [PDF]
, 2008 Pichler M. Culture formation and endogenous cultural distance. Working Papers. Institute of Mathematical Economics. Vol 403. Bielefeld: Universität Bielefeld; 2008.This paper introduces a new approach to "cultural transmission of preferences" (see Bisin ...
Pichler, Michael, Pichler, Michael M.
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