Results 201 to 210 of about 4,801,586 (249)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

open access: yesAdvanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer   +9 more
wiley   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

open access: yesAdvanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han   +11 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

open access: yesAdvanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen   +5 more
wiley   +1 more source

Cultural exposure, emotional intelligence, and cultural intelligence

International Journal of Cross Cultural Management, 2013
This study examines the influence of cultural exposure on emotional intelligence and cultural intelligence. Because of the importance of international experience in organizations, and the ease of travel, understanding the impact of exposure to other cultures is critical.
Kerri Anne Crowne
exaly   +2 more sources

Cultural Intelligence

Group & Organization Management, 2006
Are claims to describe and measure cultural intelligence credible? Three major objections are discussed: (a) Cultures are said to be entirely relative in their values, so holding one culture to be more intelligent than another is discriminatory; (b) cultural studies are said to be a form of postmodernism, whereas to have one central definition of ...
Hampden-Turner, Charles   +1 more
openaire   +2 more sources

Cultural Intelligence

2020
For individuals in management positions, globalization has reinforced contact with foreign cultures and provided opportunities to be assigned to projects abroad. Expatriates encounter additional challenges varying from differently-oriented work forces to building a new life in a foreign country.
Patrick L. Yorio   +3 more
  +5 more sources

Cultural Intelligence

International Journal of Cross Cultural Management, 2008
The construct of cultural intelligence, recently introduced to the management literature, has enormous potential in helping to explain effectiveness in cross cultural interactions. However, at present, no generally accepted definition or operationalization of this nascent construct exists.
Thomas, D. C.   +12 more
openaire   +5 more sources

Cultural Intelligence and Successful Intelligence

Group & Organization Management, 2006
Intelligence cannot be fully or even meaningfully understood outside its cultural context. Work that seeks to study intelligence a contextually risks the imposition of an investigator’s view of the world on the rest of the world. Moreover, work on intelligence within a single culture may fail to do justice to the range of skills and knowledge that may ...
Robert J. Sternberg, Elena L. Grigorenko
openaire   +1 more source

Intelligence and Culture: History and Assessment

2014
This chapter examines current views on intelligence and its assessment with a particular focus on the cultural context. The topics to be addressed are discussed in three parts: historical influences, cultural issues in conceptualizing and assessing intelligence, and adapting and developing intelligence test adaptation in the wider world.
Saklofske, Donald H.   +4 more
openaire   +4 more sources

Cultural intelligence

Proceedings of the 2009 international workshop on Intercultural collaboration, 2009
Out of the convergence of psychology and anthropology, for success in the international business community, has come the idea of cultural intelligence. What are the implications of this for missiology? Reflective intelligence refers to cognitive abilities for problem solving.
openaire   +2 more sources

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