Results 151 to 160 of about 44,773 (264)

Linking park environmental characteristics to child health outcomes: towards an evidence-based child-friendly design framework. [PDF]

Front Public Health
Zhu L, Wu L, Xu X, Hu X, Su Y.
europepmc   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Socio-cultural motives drive free-range livestock farming in Estonia. [PDF]

J Ethnobiol Ethnomed
Kalle R, Kõiva M, Molnár Z, Holm A, Kass M, Liira J.   +5 more
europepmc   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Introduction to the Special Issue on Emerging Trends of Systemic Family Therapy Around the World. [PDF]

J Marital Fam Ther
Nadan Y, Guanaes-Lorenzi C, Sesma-Vazquez M.   +2 more
europepmc   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Attribution of consciousness to non-human animals: insights from AI and multidimensional frameworks. [PDF]

Front Psychol
Chiarella SG, Laurenzi M, D'Onofrio M, Gallagher S, Raffone A.   +4 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Segmented optimization for river ecological corridor width based on ecosystem services: a case study of the North Canal River, China. [PDF]

Sci Rep
Zhu L, Wei Y, Zhao J, Yu D, Zhang W, Yan M, Xu X.   +6 more
europepmc   +1 more source

Productive landscapes and the cultural historical environment : Prototyping a small-scale productive system utilizing the immediate landscape

, 2019
The thesis is an investigation of global exploitation of nature, use of productive landscapes and itsremaining structures as the cultural historical environment. The further aim has been to seek analternative approach against a large-scale utilization of the environment through an elaborativeprocess of an architectural intervention, combining public ...
openaire   +1 more source