Results 191 to 200 of about 92,421 (253)

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Cultural threads of memory: barriers and motivations for brain health, physical activity and nutrition among middle-aged and older Latinos. [PDF]

Ethn Health
Guzman J, Soto Y, Aguiñaga S, Aguirre K, Marques I, Vasquez PM, Wilcox S, Marquez DX.   +7 more
europepmc   +1 more source

NIR‐II Light‐Triggered Electron Flow Initiates Cuproptosis‐Centered Thermoelectric‐Immunotherapy for Breast Cancer

Advanced Science, EarlyView.
A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan, Qin Fan, Shushu Chu, Shining Yang, Yuechao Yang, Chenxi Zhang, Jinqiao Zhang, Xinran Qu, Yiju Wei, Xin Wang, Ziliang Dong   +10 more
wiley   +1 more source

The unsung heroes of traditional healers in healing and traditional medicine in dementia care for Indigenous populations in North America: an exploration of a compassionate, community-led care model. [PDF]

Front Public Health
Shrestha HL, Shrestha L, Rosich RM, Splaine M, Petahtegoose A.   +4 more
europepmc   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Resonance across cultures and faiths: examining the violin music's role in emotional, psychological, and spiritual well-being for sustainable societies. [PDF]

Front Psychiatry
Zhang S.
europepmc   +1 more source

A Printed Hydrogel Hybrid Electronic System With Thermoresponsive Adhesion for Neurophysiological Monitoring

Advanced Science, EarlyView.
This work develops a soft hybrid electronic system with printed thermoresponsive hydrogel electrodes, which enables high‐fidelity neural signal acquisition and stimulation. The system precisely assesses median and ulnar nerve injuries in clinical cases, realizing accurate diagnosis of neural impairment while ensuring customized adhesion regulation ...
Bo Pang, Ganguang Yang, Jiacheng Wen, Hangyu Gong, Caixin Gong, Yuqi Qiu, Zhixin Wang, Qingyang Zheng, Sen Zhou, Tianzhao Bu, Jia Tian, Zhouping Yin, Yutian Liu, Hao Wu   +13 more
wiley   +1 more source

Executive Function from Observation and Reflection Tool (EFFORT): Validation of a Culturally Adaptable and Publicly Available Item Bank in Seven Countries. [PDF]

Behav Sci (Basel)
Obradović J, Ahmed I, Mazzaferro M, Sulik MJ, McCoy DC, Wolf S, Draper CE, D'Sa N, Howard SJ, Lipina S, Thennakoon K, Ghalibaf E.   +11 more
europepmc   +1 more source

Effects of HIV and Adverse Childhood Experiences on Neurocognition. [PDF]

J Acquir Immune Defic Syndr
Inman EM, Inman EM, Ramsammy CW, Kalegina A, Robbins RN, Violari A, Kidman R.   +6 more
europepmc   +1 more source