Advanced Science, EarlyView.In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin +13 more
wiley +1 more source
The Danish Cultural Heritage: Economics and Politics [PDF]
This paper deals with the Danish cultural heritage understood as the tangible heritage, mainly buildings. The paper briefly describes the political economy of conserving the cultural heritage and the means of preserving it. The main focus of the paper is,
Chr. Hjorth-Andersen
core
Construction of early childhood and ECCD service provisioning in India [PDF]
, 2011 There has been a growing recognition among scholars in childhood studies that childhood is a social construction. Several historical and cross-cultural studies conducted across the world validate this argument, and whereby explains the variability that ...
Aruldoss, Vinnarasan
core
A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer
Advanced Science, EarlyView.A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang +15 more
wiley +1 more source
Commercial Culture, Political Culture and the Political Economy of Trade Policy: The Case of Japan [PDF]
In this paper we present a model of endogenous trade-policy formation which captures crucial aspects of the Japanese commercial and political culture.
Heinrich Ursprung, Seiichi Katayama
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Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
Advanced Science, EarlyView.This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
Case study report The perception of the EU cultural and science diplomacy in Turkey. EL-CSID Working Paper Issue 2018/14 • April 2018 [PDF]
, 2018 The study is undertaken in the framework of the European Leadership in Cultural, Science and Innovation Diplomacy (EL-CSID) project. This project has the ambition to codify and articulate the relevance of cultural, science and innovation diplomacy for EU
Senocak, Naciye Selin
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Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
COPYRIGHT PROTECTION FOR CREATIVE INDUSTRIES: COMPARISON AMONG CHINA AND EUROPE [PDF]
Challenges of the Knowledge Society, 2013 The impact and creativity has increase in the last years in Europe. It was focused by an United Nations report on creative economy in 2008 .Cooperation and trade in goods and services has increased.
CRISTINA ORTEGA NUERE +1 more
doaj
Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China
Advanced Science, EarlyView.This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang +3 more
wiley +1 more source