Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment
Advanced Science, EarlyView.This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang +7 more
wiley +1 more source
Are the Australian Dietary Guidelines Fit for Purpose for Culturally Diverse Populations? A Qualitative Study. [PDF]
Health Promot J AustrNarsh H, Gallegos D.
europepmc +1 more source
Advanced Science, EarlyView.Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge +9 more
wiley +1 more source
Exploring spatial heterogeneity and influencing factors of cultural inheritance level in mountain traditional villages: a case of Leishan County. [PDF]
Sci RepWei H, Fan L, Wu C.
europepmc +1 more source
Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Advanced Science, EarlyView.Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
Domestic violence and social policy formation in Palestine: an explanatory sequential mixed-methods study. [PDF]
Front SociolShobaki A, Al-Shafai N.
europepmc +1 more source
A value based approach to assessing changes in cultural policies
, 2021 Kimberly Mlitz +1 more
openalex +2 more sources
TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2
Advanced Science, EarlyView.This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao +12 more
wiley +1 more source
Multisectoral policy and health systems responses to ageing populations. [PDF]
Bull World Health OrganTangcharoensathien V +4 more
europepmc +1 more source