Results 91 to 100 of about 2,908,916 (364)

Cultural Practices as a Tool for the Tourist Destination Development

open access: yesКультура і мистецтво у сучасному світі
The aim of the article is to analyse the functional peculiarities of cultural practices under the conditions of transforming tourist destinations in Ukraine. Results.
Olha Kopiievska
doaj   +1 more source

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1155-1169, April 2025.
We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park   +8 more
wiley   +1 more source

The Tensions between Ukuthwasa and Labour Laws in South Africa: A Human Rights-Based Approach [PDF]

open access: yesE-Journal of Humanities, Arts and Social Sciences
This paper appraises the tensions between the cultural practice of ukuthwasa and fundamental human rights in South Africa. This is particularly within the context of modern labour laws and workplace practices. A doctrinal research methodology is employed
Stewart Lee Kugara   +1 more
doaj   +1 more source

Digital transformation in the arts : a case study [PDF]

open access: yes, 2012
This paper considers the interaction between digital technology and cultural organisations and the challenges and opportunities this presents for practice and for policy.
Bilton, Chris, Leary, Ruth
core  

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Genomic landscape and preclinical models of angiosarcoma

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 965-983, April 2025.
Angiosarcomas are a rare and aggressive cancer with a poor prognosis for patients. The genomic landscape of angiosarcoma can be highly complex and heterogenous; however, recent studies have identified some common features especially within anatomic and molecular subgroups.
Annaleigh Benton   +3 more
wiley   +1 more source

“Between the Useful and the Beautiful”: Reading, Power and Pleasure in the Residencia de Señoritas (1930-1936)

open access: yesCulture & History Digital Journal, 2019
In the early 20th century many spaces of female sociability in Spain were characterised by the creation of habits, dispositions and forms of knowledge in University women.
Débora Betrisey Nadali
doaj   +1 more source

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1203-1228, April 2025.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso   +12 more
wiley   +1 more source

The axiological potential of the holiday in the development of the collective memory

open access: yesCхід, 2019
The axiological potential of the holiday is uncovered in the article not as the form of the collective memory because of as the integral part of the culture which is appeared with the formation of the human society and it is accompanied it during all ...
Olena Troitska   +2 more
doaj   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

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