Results 131 to 140 of about 3,202,546 (362)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Culturally Sustaining Early Literacy Teaching: Research on New Approaches, Practices, and Strategies [PDF]
, 2019 Kindel Nash
openalex +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Instructional Ribbing as a Cultural Practice for Guiding Children. [PDF]
Hum Dev, 2020 Silva KG, Rogoff B.
europepmc +1 more source
Radical research as research at the roots: Practitioner self-image, public relations and ethics [PDF]
, 2008 Semantically, radical derives from ‘radix’, the Latin for root. This paper argues that little public relations research goes back to the roots of actual practice and addresses this neglect through a project focusing on practitioner accounts of their work.
Toledano, Margalit
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
A Guide to Distributed Digital Preservation [PDF]
, 2010 This volume is devoted to the broad topic of distributed digital preservation, a still-emerging field of practice for the cultural memory arena. Replication and distribution hold out the promise of indefinite preservation of materials without degradation,
Schultz, Matt, Skinner, Katherine
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Acta Scientiarum Polonorum: Hortorum Cultus, 2013 The response of berry organic acids of four organically grown table grape cultivars to cane-girdling and cluster-berry thinning treatments were evaluated over two growing seasons.
Nurhan Keskin +2 more
doaj
Cultural Determinants of Help Seeking: A Model for Research and Practice [PDF]
, 2009 Denise Saint Arnault
openalex +1 more source