3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes +11 more
wiley +1 more source
Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su +8 more
wiley +1 more source
Determination of the temporal-spatial pattern distribution and evolution of industrial heritage in Northeast China and its influencing factors. [PDF]
Ban Y, Chen J, Liu C, Wang J, Liu J.
europepmc +1 more source
Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad +6 more
wiley +1 more source
Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings
Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed +9 more
wiley +1 more source
Retail black economic empowerment compliant companies: cultural renewal in South Africa [PDF]
Louise van Scheers
doaj
From awareness to understanding: translating mental health literacy into inclusive and empathic practice. [PDF]
El-Gabry DA.
europepmc +1 more source
Celebrating the mosaic: a perspective on Lutheran worship in Canada [PDF]
Nostbakken, Roger W.
core +1 more source
Smart Closed‐Loop Systems in Personalized Healthcare: Advances and Outlook
A smart closed‐loop e‐textile integrates multimodal sensing, onboard processing, wireless communication, and wearable power to enable real‐time physiological/biochemical monitoring and feedback‐controlled therapy. ABSTRACT Smart textiles represent a revolutionary frontier in healthcare, seamlessly blending fabric and advanced technologies to create ...
Safoora Khosravi +12 more
wiley +1 more source
Urban health research: shaping integrated policies for health, equity, sustainability, and climate. [PDF]
Subiza-Pérez M +5 more
europepmc +1 more source

