Results 141 to 150 of about 5,575,282 (351)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The Kurds in Turkey: Context and Current Status
Migracijske i etničke teme, 2001 The paper proposes to examine two variables in connection with the Kurdish presence in Turkey: 1) the intensity of expression of Kurdish nationalism, and 2) repercussions of the Kurdish question on Turkey.
Simon Haddad
doaj
Are (Should) Human Rights (Be) Universal? [PDF]
, 1998 Many critics of the concept of human rights argue that it undermines indigenous cultures, especially in the underdeveloped world. I agree that the concept of human rights often undermines cultures.
Howard-Hassmann, Rhoda E.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Are cultural rights human rights? A cosmopolitan conception of cultural rights
, 2016 The liberal conception of the state is marked by an insistence upon the equal civil and political rights of each inhabitant. Recently, though, a number of writers have argued that this emphasis on uniform rights ignores the fact that the populations of most states are culturally diverse, and that their inhabitants have significant interests qua members
Metcalfe, E, Metcalfe, Eric
openaire +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Cultural districts and economic development [PDF]
The aim of this paper is to analyze the economic properties as well as tbe institutions governing the start-up and the evolution of cultural districts. Cultural districts are a good example of economic development based on localized culture.
Santagata Walter
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Snapshots From the Margins: Transgressive Cosmopolitanisms in Europe [PDF]
, 2014 Right-wing parties and governments in Europe have recently expressed greater hostility towards cultural pluralism, at times officially denunciating multiculturalism, and calling for the closure of borders and denial of rights to non-European nationals ...
Baban, Feyzi, Rygiel, Kim
core +1 more source