Results 201 to 210 of about 147,343 (354)

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

A study on the problems of China's cultural security

, 2010
碩士本研究旨在探討在全球化、國際交往、內部社會問題等諸多因素影響下，中國的文化安全問題，以及中國對於自身所處的文化困境將如何因應並尋求解決之道。其研究目的有三：一、探討中國文化安全問題產生的因素；二、分析中共因應國家文化安全所採取的方式；三、中國面臨且尚待解決的文化安全問題。 本文研究範圍朔及毛澤東、鄧小平、江澤民、胡錦濤四代領導人，以2006年9月13日，中共頒布中國「國家『十一五』時期文化發展規劃綱要」，為研究時間範圍的終點。不過由於文化範疇過於廣泛，本文無法針對單一課題進行深入的研究與探討。
陳筑君; Chen, Chu-chun
core  

Advancing food equity through explainable AI: identifying place-based factors and conditions of food security. [PDF]

Front Public Health
Hoglund L, Park H.
europepmc   +1 more source

ABOUT SECURITY CULTURE

Annals: Series on Military Sciences, 2016
Security culture focuses on a broader scope: the ideas, customs and social behaviors, values of a group that influence the group and also society security at large. Therefore, there is a need to know the cyber risk, the geopolitical influence, the means of preventing terrorism, the security institutions, the warfare information for confronting these ...
openaire   +1 more source

Multi-cultural network security

, 1996
D.F. Stevens
openalex   +1 more source

Corporate apology and cultural difference: A comparison of the United States and South Korea in cyber-security breach crisis

, 2017
Nahyun Kim
openalex   +2 more sources

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Motives of Indian Nurses Moving to Germany in the Context of Skilled Labor Migration in Healthcare. [PDF]

Nurs Rep
Pilz M, Sterzenbach L, Albertz A.
europepmc   +1 more source

AN ASSESSMENT OF THE IMPACTS OF REFUGEES' PRESENCE ON THE ECONOMIC, SOCIO-CULTURAL AND SECURITIES OF THE HOST COMMUNITIES OF GOG WOREDA, CASE STUDY OF PUGNIDO REFUGEE CAMP.

Zelalem Sileshi
openalex   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source